NEJM:老年房颤患者低剂量依度沙班的疗效分析

2020-10-29 MedSci原创 MedSci原创

在非瓣膜性心房颤动老年患者中,它们不适合作为标准剂量的口服抗凝药,在预防卒中或全身性栓塞方面,每天一次15 mg的依度沙班优于安慰剂,且未导致严重出血发病率明显升高。

由于担心出血,在非常年老的房颤患者中给予适当的口服抗凝治疗以预防卒中具有挑战性。

近日,顶级医学期刊NEJM上发表了一篇研究文章,研究人员进行了一项三期、多中心、随机、双盲、安慰剂对照试验,比较了日本老年人(≥80岁)非瓣膜性房颤患者每天一次15 mg依度沙班与安慰剂治疗的疗效。该研究的主要疗效终点是根据国际血栓形成和止血协会定义的卒中或全身性栓塞的综合事件,主要安全终点是严重出血。

该研究共纳入984名患者,以1:1的比例被随机分配,以接受每日15mg的依度沙班(492例)或安慰剂(492例)治疗,共有681名患者完成了试验,其中303名患者终止了试验(158名退出了试验,135例死亡,还有10例因其他原因终止);两组终止试验的患者人数相似。依度沙班组卒中或全身性栓塞的年化率为2.3%,安慰剂组为6.7%(风险比为0.34;95%置信区间[CI]为0.19至0.61;P<0.001),且依多沙班组大出血率为3.3%,安慰剂组为1.8%(风险比为1.87; 95%CI为0.90至3.89;P=0.09)。依度沙班组胃肠道出血事件多于安慰剂组。两组之间因任何原因死亡的差异均无实质性差异(依度沙班组为9.9%,安慰剂组为10.2%;风险比为0.97;95%CI为0.69至1.36)。

由此可见,在非瓣膜性心房颤动老年患者中,它们不适合作为标准剂量的口服抗凝药,在预防卒中或全身性栓塞方面,每天一次15 mg的依度沙班优于安慰剂,且未导致严重出血发病率明显升高。
 
原始出处:
 
Ken Okumura,et al.Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation.NEJM.2020.https://www.nejm.org/doi/full/10.1056/NEJMoa2012883

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    2020-10-30 咻凡

    由于担心出血,在非常年老的房颤患者中给予适当的口服抗凝治疗以预防卒中具有挑战性。

    0

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    2020-10-29 Lexi

    在非瓣膜性心房颤动老年患者中,它们不适合作为标准剂量的口服抗凝药,在预防卒中或全身性栓塞方面,每天一次15 mg的依度沙班优于安慰剂,且未导致严重出血发病率明显升高。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1647283, encodeId=fae7164e283e1, content=<a href='/topic/show?id=e9bae04003f' target=_blank style='color:#2F92EE;'>#疗效分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70400, encryptionId=e9bae04003f, topicName=疗效分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=219323401160, createdName=rebeccajiejie, createdTime=Tue Jul 06 23:26:09 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480584, encodeId=6132148058473, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sat Oct 31 00:26:09 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614565, encodeId=1abd161456595, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Sat Oct 31 00:26:09 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895665, encodeId=14a589566500, content=由于担心出血,在非常年老的房颤患者中给予适当的口服抗凝治疗以预防卒中具有挑战性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Oct 30 16:09:02 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895416, encodeId=640989541615, content=在非瓣膜性心房颤动老年患者中,它们不适合作为标准剂量的口服抗凝药,在预防卒中或全身性栓塞方面,每天一次15 mg的依度沙班优于安慰剂,且未导致严重出血发病率明显升高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Oct 29 15:23:22 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031316, encodeId=1666103131663, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032694, encodeId=98811032694bb, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035473, encodeId=2db110354e3b3, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895277, encodeId=8bf98952e7f0, content=老年<a href='/topic/show?id=737a54248f5' target=_blank style='color:#2F92EE;'>#房颤#</a>患者低剂量<a href='/topic/show?id=5aae26890c0' target=_blank style='color:#2F92EE;'>#依度沙班#</a>, 小剂量的沙班类药物,并不亚于<a href='/topic/show?id=23959394eda' target=_blank style='color:#2F92EE;'>#达比加群#</a>这一类NOAC, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54248, encryptionId=737a54248f5, topicName=房颤), TopicDto(id=26890, encryptionId=5aae26890c0, topicName=依度沙班), TopicDto(id=93947, encryptionId=23959394eda, topicName=达比加群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:34:52 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-10-29 心介

    房颤,临床上碰到很多哦

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1647283, encodeId=fae7164e283e1, content=<a href='/topic/show?id=e9bae04003f' target=_blank style='color:#2F92EE;'>#疗效分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70400, encryptionId=e9bae04003f, topicName=疗效分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=219323401160, createdName=rebeccajiejie, createdTime=Tue Jul 06 23:26:09 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480584, encodeId=6132148058473, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sat Oct 31 00:26:09 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614565, encodeId=1abd161456595, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Sat Oct 31 00:26:09 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895665, encodeId=14a589566500, content=由于担心出血,在非常年老的房颤患者中给予适当的口服抗凝治疗以预防卒中具有挑战性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Oct 30 16:09:02 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895416, encodeId=640989541615, content=在非瓣膜性心房颤动老年患者中,它们不适合作为标准剂量的口服抗凝药,在预防卒中或全身性栓塞方面,每天一次15 mg的依度沙班优于安慰剂,且未导致严重出血发病率明显升高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Oct 29 15:23:22 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031316, encodeId=1666103131663, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032694, encodeId=98811032694bb, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035473, encodeId=2db110354e3b3, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895277, encodeId=8bf98952e7f0, content=老年<a href='/topic/show?id=737a54248f5' target=_blank style='color:#2F92EE;'>#房颤#</a>患者低剂量<a href='/topic/show?id=5aae26890c0' target=_blank style='color:#2F92EE;'>#依度沙班#</a>, 小剂量的沙班类药物,并不亚于<a href='/topic/show?id=23959394eda' target=_blank style='color:#2F92EE;'>#达比加群#</a>这一类NOAC, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54248, encryptionId=737a54248f5, topicName=房颤), TopicDto(id=26890, encryptionId=5aae26890c0, topicName=依度沙班), TopicDto(id=93947, encryptionId=23959394eda, topicName=达比加群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:34:52 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-10-29 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1647283, encodeId=fae7164e283e1, content=<a href='/topic/show?id=e9bae04003f' target=_blank style='color:#2F92EE;'>#疗效分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70400, encryptionId=e9bae04003f, topicName=疗效分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=219323401160, createdName=rebeccajiejie, createdTime=Tue Jul 06 23:26:09 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480584, encodeId=6132148058473, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sat Oct 31 00:26:09 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614565, encodeId=1abd161456595, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Sat Oct 31 00:26:09 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895665, encodeId=14a589566500, content=由于担心出血,在非常年老的房颤患者中给予适当的口服抗凝治疗以预防卒中具有挑战性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Oct 30 16:09:02 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895416, encodeId=640989541615, content=在非瓣膜性心房颤动老年患者中,它们不适合作为标准剂量的口服抗凝药,在预防卒中或全身性栓塞方面,每天一次15 mg的依度沙班优于安慰剂,且未导致严重出血发病率明显升高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Oct 29 15:23:22 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031316, encodeId=1666103131663, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032694, encodeId=98811032694bb, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035473, encodeId=2db110354e3b3, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895277, encodeId=8bf98952e7f0, content=老年<a href='/topic/show?id=737a54248f5' target=_blank style='color:#2F92EE;'>#房颤#</a>患者低剂量<a href='/topic/show?id=5aae26890c0' target=_blank style='color:#2F92EE;'>#依度沙班#</a>, 小剂量的沙班类药物,并不亚于<a href='/topic/show?id=23959394eda' target=_blank style='color:#2F92EE;'>#达比加群#</a>这一类NOAC, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54248, encryptionId=737a54248f5, topicName=房颤), TopicDto(id=26890, encryptionId=5aae26890c0, topicName=依度沙班), TopicDto(id=93947, encryptionId=23959394eda, topicName=达比加群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:34:52 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-10-29 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1647283, encodeId=fae7164e283e1, content=<a href='/topic/show?id=e9bae04003f' target=_blank style='color:#2F92EE;'>#疗效分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70400, encryptionId=e9bae04003f, topicName=疗效分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=219323401160, createdName=rebeccajiejie, createdTime=Tue Jul 06 23:26:09 CST 2021, time=2021-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480584, encodeId=6132148058473, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Sat Oct 31 00:26:09 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614565, encodeId=1abd161456595, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Sat Oct 31 00:26:09 CST 2020, time=2020-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895665, encodeId=14a589566500, content=由于担心出血,在非常年老的房颤患者中给予适当的口服抗凝治疗以预防卒中具有挑战性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Oct 30 16:09:02 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895416, encodeId=640989541615, content=在非瓣膜性心房颤动老年患者中,它们不适合作为标准剂量的口服抗凝药,在预防卒中或全身性栓塞方面,每天一次15 mg的依度沙班优于安慰剂,且未导致严重出血发病率明显升高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Thu Oct 29 15:23:22 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031316, encodeId=1666103131663, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032694, encodeId=98811032694bb, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035473, encodeId=2db110354e3b3, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 29 12:26:09 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=895277, encodeId=8bf98952e7f0, content=老年<a href='/topic/show?id=737a54248f5' target=_blank style='color:#2F92EE;'>#房颤#</a>患者低剂量<a href='/topic/show?id=5aae26890c0' target=_blank style='color:#2F92EE;'>#依度沙班#</a>, 小剂量的沙班类药物,并不亚于<a href='/topic/show?id=23959394eda' target=_blank style='color:#2F92EE;'>#达比加群#</a>这一类NOAC, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54248, encryptionId=737a54248f5, topicName=房颤), TopicDto(id=26890, encryptionId=5aae26890c0, topicName=依度沙班), TopicDto(id=93947, encryptionId=23959394eda, topicName=达比加群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Oct 29 09:34:52 CST 2020, time=2020-10-29, status=1, ipAttribution=)]
    2020-10-29 lovetcm

    老年#房颤#患者低剂量#依度沙班#, 小剂量的沙班类药物,并不亚于#达比加群#这一类NOAC

    0

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