J Clin Periodontol:全身辅助应用叶酸有助于改善牙周炎的治疗效果

2021-04-14 MedSci原创 MedSci原创

营养素的补充被认为是牙周病治疗的辅助手段,血清叶酸(FA)低和膳食中FA摄入不足与牙周健康恶化有关。近日,研究人员评估了辅助全身摄入叶酸(FA)与洁治和根面平整(SRP)治疗牙周炎的临床和生化效果,研

营养素的补充被认为是牙周病治疗的辅助手段,血清叶酸(FA)低和膳食中FA摄入不足与牙周健康恶化有关。近日,研究人员评估了辅助全身摄入叶酸(FA)与洁治和根面平整(SRP)治疗牙周炎的临床和生化效果,研究结果已发表于J Clin Periodontol。

研究纳入60名牙周炎患者,随机分配分别接受SRP+安慰剂(SRP+P)或SRP+叶酸(SRP+F)治疗。除了临床参数(菌斑指数[PI]、牙龈指数[GI]、探诊深度[PPD]、临床附着水平[CAL]和牙龈退缩[GR])外,还在基线和治疗后(PT)时期(1个月(PT-1)、3个月(PT-3)和6个月(PT-6))获得龈沟液(GCF)样本,以评估C反应蛋白(CRP)和同型半胱氨酸(Hcy)的水平。

 

结果显示,两组患者的所有临床参数均显著降低,且具有时间依赖性(P < .001)。与SRP + P组相比,SRP + F组患者在PT-1(p = .004)和PT-3(p = .035)时CAL较低,而GR仅在PT-1时较低(p = .015)。GCF量和CRP没有组间差异,而SRP + F组的Hcy在PT-3(p = .044)和PT-6(p = .041)时较高。GCF量和Hcy在两组治疗后均显示减少(p < .001)。

综上所述,该研究结果表明,两种治疗方式均可改善患者的临床和生化参数。推荐全身辅助应用FA治疗牙周炎,以改善治疗效果,但其影响机制应进一步阐明。

 

原始出处:

 

H Gencay Keceli, et al., The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C-reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo-controlled clinical trial. J Clin Periodontol. 2020 May;47(5):602-613. doi: 10.1111/jcpe.13276. 

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    2022-05-17 赛华佗

    #叶酸##牙周炎#这是不多见的研究,将二者关联起来

    0

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    2021-08-14 feather89
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content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Apr 16 13:08:30 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957438, encodeId=745d95e43811, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df5f1662034, createdName=1ddef583m60(暂无匿称), createdTime=Thu Apr 15 22:29:54 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957188, encodeId=952c95e188dd, content=学习无止境, beContent=null, 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CST 2021, time=2021-04-15, status=1, ipAttribution=)]
  5. 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authenticateStatus=null, createdAvatar=null, createdBy=cdf05480664, createdName=ms5000000023660064, createdTime=Thu Apr 15 06:58:48 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032875, encodeId=bb0310328e5b5, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047321, encodeId=c7d7104e3214c, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 1ddef583m60(暂无匿称)

    涨知识了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1220357, encodeId=4a9c122035eba, content=<a href='/topic/show?id=5da438e035f' target=_blank style='color:#2F92EE;'>#叶酸#</a>与<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>这是不多见的研究,将二者关联起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38703, encryptionId=5da438e035f, topicName=叶酸), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Tue May 17 16:24:39 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894212, encodeId=1a25189421290, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, 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authenticateStatus=null, createdAvatar=null, createdBy=cdf05480664, createdName=ms5000000023660064, createdTime=Thu Apr 15 06:58:48 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032875, encodeId=bb0310328e5b5, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047321, encodeId=c7d7104e3214c, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 ms4000000739766810

    学习无止境

    0

  7. 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CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 1244c0ebm28暂无昵称

    学习学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1220357, encodeId=4a9c122035eba, content=<a href='/topic/show?id=5da438e035f' target=_blank style='color:#2F92EE;'>#叶酸#</a>与<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>这是不多见的研究,将二者关联起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38703, encryptionId=5da438e035f, topicName=叶酸), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Tue May 17 16:24:39 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894212, encodeId=1a25189421290, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, 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content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Fri Apr 16 13:08:30 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957438, encodeId=745d95e43811, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df5f1662034, createdName=1ddef583m60(暂无匿称), createdTime=Thu Apr 15 22:29:54 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957188, encodeId=952c95e188dd, content=学习无止境, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3ba65480677, createdName=ms4000000739766810, createdTime=Thu Apr 15 09:02:10 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957181, encodeId=ee2295e1819a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Thu Apr 15 08:45:52 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957158, encodeId=3f9595e158ae, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cdf05480664, createdName=ms5000000023660064, createdTime=Thu Apr 15 06:58:48 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032875, encodeId=bb0310328e5b5, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047321, encodeId=c7d7104e3214c, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 ms5000000023660064

    学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1220357, encodeId=4a9c122035eba, content=<a href='/topic/show?id=5da438e035f' target=_blank style='color:#2F92EE;'>#叶酸#</a>与<a href='/topic/show?id=5cc96e515a9' target=_blank style='color:#2F92EE;'>#牙周炎#</a>这是不多见的研究,将二者关联起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38703, encryptionId=5da438e035f, topicName=叶酸), TopicDto(id=67515, encryptionId=5cc96e515a9, topicName=牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Tue May 17 16:24:39 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894212, encodeId=1a25189421290, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, 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authenticateStatus=null, createdAvatar=null, createdBy=cdf05480664, createdName=ms5000000023660064, createdTime=Thu Apr 15 06:58:48 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032875, encodeId=bb0310328e5b5, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047321, encodeId=c7d7104e3214c, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

  10. 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authenticateStatus=null, createdAvatar=null, createdBy=cdf05480664, createdName=ms5000000023660064, createdTime=Thu Apr 15 06:58:48 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032875, encodeId=bb0310328e5b5, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047321, encodeId=c7d7104e3214c, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Apr 15 01:08:30 CST 2021, time=2021-04-15, status=1, ipAttribution=)]
    2021-04-15 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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