J Gastroenterology:存在腹水的肝硬化患者使用利尿剂对肌肉痉挛的影响

2020-06-22 MedSci原创 MedSci原创

据报道,存在腹水的肝硬化患者使用利尿剂与肌肉痉挛有关。但是,临床证据有限。这项研究旨在确定肌肉痉挛是否是利尿药引起的并发症,以及腹水是否与肌肉痉挛有关。

背景:

据报道,存在腹水的肝硬化患者使用利尿剂与肌肉痉挛有关。但是,临床证据有限。这项研究旨在确定肌肉痉挛是否是利尿药引起的并发症,以及腹水是否与肌肉痉挛有关。

方法:

研究人员收集了在2017年6月至2018年12月期间在日本10家医院的1064名成人肝硬化患者。所有患者均完成了有关肌肉痉挛的问卷调查。同时,研究人员使用生物电阻抗分析法分析细胞外水(ECW)的比例。进行逻辑回归分析以分析利尿剂给药和ECW比率对肌肉痉挛的影响。

结果:

研究结果显示与未使用利尿剂的患者相比,使用利尿剂的患者发生肌肉痉挛的比例更高,频率更高,疼痛更严重,抽筋时间更长。在多变量分析中,利尿剂的使用和ECW比值≥0.4与肌肉痉挛的存在,频率,强度或持续时间没有显着相关。但是,对于处于Child–Pugh B或C的患者,利尿剂的使用与肌肉痉挛的频率显着相关。

结论:

这些结果表明,在肝硬化患者中,肌肉抽筋不是利尿剂使用的并发症。但是,在仅限于Child–Pugh B或C的人群中,利尿剂使用是影响抽筋发生频率的因素。

原始出处:

Yasuhiko Sawada. et al. The effects of diuretic use and the presence of ascites on muscle cramps in patients with cirrhosis: a nationwide study.J Gastroenterology.2020.

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    2020-10-09 许安
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    2020-06-24 apoenzyme
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    2020-06-22 guging

    谢谢!最新的信息读起来就是收获大

    0

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