JCEM:血钠水平对卒中患者功能结局的影响

2021-09-11 MedSci原创 MedSci原创

在住院的急性卒中患者中,持续性低钠血症与较差的功能结局相关。积极纠正低钠血症能否改善预后仍有待前瞻性研究进行检验。

入院低钠血症与卒中患者较差的临床结局相关,但纠正低钠血症是否能改善结局尚未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在调查纠正低钠血症是否会影响患者三个月内的残疾、死亡率和卒中复发;住院时间和出院后去向。

这项研究是对2016年1月至2018年12月期间收集的数据进行的基于注册表的分析。研究人员将来自瑞士卒中登记处(SSR)的数据与电子患者记录相关联,以提取患者的血钠数据。研究人员分析了在巴塞尔大学医院接受治疗的住院患者的数据。该研究的主要结果指标为三个月时的改良Rankin量表(mRS)评分。


1995名患者中,144名(7.2%)入院时出现低钠血症;102人(70.8%)达到正常血钠水平,42人(29.2%)出院时仍为低钠血症。血钠的增加与三个月时更好的功能结局相关(OR为0.94,95%CI为[0.90-0.99],血钠每增加1mmol/L获得更高的mRS得分)。与血钠正常的患者相比,出院时仍保持低血钠的患者在三个月时的功能结局更差(OR为2.46,95%CI为[1.20-5.03])。该研究未发现血钠对死亡率、复发或住院时间有影响。
 
由此可见,在住院的急性卒中患者中,持续性低钠血症与较差的功能结局相关。积极纠正低钠血症能否改善预后仍有待前瞻性研究进行检验。

原始出处:

Laura Potasso.et al.Impact of Sodium Levels on Functional Outcomes in Patients with Stroke – A Swiss Stroke Registry Analysis.JCEM.2021.https://doi.org/10.1210/clinem/dgab650

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    2021-11-12 仁心济世
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    2022-06-03 achengzhao
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    2021-10-11 hmwwww
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    2021-09-12 沐雨海马

    是否与提高血钠缓解脑组织水肿有关系

    0

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    2021-09-11 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2021-09-11 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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