Eur J Heart Fail:急性心力衰竭住院后的长期生存和预期寿命

2022-07-03 MedSci原创 MedSci原创

与普通人群相比,因HF住院的患者中只有不到1/5的患者存活10年,患者的预期寿命下降了近60%,这突出了HF相当持久的社会负担。需要协同的多学科努力来改善HF住院治疗后的结局。

心衰住院治疗后的当代长期生存率并不确定。近日,心血管领域权威杂志European Journal of Heart Failure上发表了一篇研究文章,研究人员利用澳大利亚和新西兰的国家数据评估心衰患者住院后10年的生存率,并确定生存率的预测因素,以及估计可归因于预期寿命的损失。

研究人员通过与死亡登记处联系,确定了2008-17年期间住院的初步诊断为心衰的患者,并评估了全因死亡率。灵活的参数生存模型用于估计生存、生存预测和预期寿命的损失。

研究人员纳入了283048例HF患者(平均年龄为78.2±12.3岁,50.8%为男性)。其中3年生存率为48.3%(48.1-48.5),5年生存率为34.1%(33.9-34.3),10年生存率为17.1%(16.8-17.4)(中位生存率为2.8年)。生存期随年龄的增长而下降,年龄在18-54岁的患者中有53.4%,年龄≥85岁的患者有6.2%的10年生存期(≥85岁的患者与18-54岁的患者相比,调整后的风险比[aHR]为4.84;95%CI为4.65-5.04),男性患者的生存期更差(aHR为1.14;95%CI1.13-1.15)。

既往HF(aHR为1.20;95%CI为1.18-1.22)、瓣膜病和风湿性心脏病(aHR为1.11;95%CI为1.10-1.13)和血管疾病(aHR为1.07;95%CI为1.04-1.09)是与长期死亡密切相关的心血管合并症。非心血管合并症和老年综合征是常见的,并与较高的死亡率相关。与普通人群相比,HF与预期寿命减少7.3年(或预期寿命的56.6%)相关,18-54岁的人群达到20.5年。

由此可见,与普通人群相比,因HF住院的患者中只有不到1/5的患者存活10年,患者的预期寿命下降了近60%,这突出了HF相当持久的社会负担。需要协同的多学科努力来改善HF住院治疗后的结局。

原始出处:

Saranya Hariharaputhiran.et al.Long-term Survival and Life Expectancy Following an Acute Heart Failure Hospitalisation in Australia and New Zealand.European journal of heart failure.2022.https://onlinelibrary.wiley.com/doi/abs/10.1002/ejhf.2595

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    2022-07-03 zhaojie88
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    2022-07-03 slcumt
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    2022-07-03 huaguang

    心衰的生存率随着年龄增加而减少

    0

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