Eur Respir J:哮喘患者骨质疏松和脆性骨折发病率

2020-08-10 MedSci原创 MedSci原创

哮喘患者比普通人群更容易发生骨质疏松症或FF,尤其是年轻人和使用OCS和ICS的个体。

骨质疏松和脆性骨折(FF)与皮质类固醇激素使用有关,皮质类固醇激素是哮喘的主要治疗药物。然而,哮喘患者这些骨合并症尚未得到很好的描述。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员使用临床实践研究数据库(CPRD)进行了一项配对队列研究。根据年龄、性别和习俗,确定并匹配了具有哮喘发作代码的成人,并随机选择了多达4个没有哮喘的个体。研究人员计算了骨质疏松症和FF发生率,并进行Cox回归,并获得与一般人群相比较的风险比。研究人员报告了年龄、性别、糖皮质激素的影响以及特定骨折的风险。

哮喘患者发生骨质疏松症的风险比普通人群高(aHR = 1.18,95%CI:1.13-1.23),而发生FF的可能性高出12%(aHR=1.12,95%CI:1.07-1.16)。年龄可调整哮喘对骨质疏松症和FF的影响,从而使这种影响在年轻人中更强(交互作用P<0.0001)。椎骨(aHR=1.40,95%CI:1.33–1.48)和前臂腕(aHR=1.27,95%CI:1.22-1.32)是骨折发生率较高的部位。研究人员观察到口服皮质类固醇(OCS)与骨质疏松症之间存在剂量反应关系,而每年进行6次或以上OCS疗程的患者发生FF的风险增加。定期使用吸入性糖皮质激素(ICS)会使两种骨病的风险增加。

由此可见,哮喘患者比普通人群更容易发生骨质疏松症或FF,尤其是年轻人和使用OCS和ICS的个体。

原始出处:

Christos V. Chalitsios,et al.Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study.Eur Respir J.2020.https://erj.ersjournals.com/content/early/2020/08/03/13993003.01251-2020

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    2020-08-12 Eleven17
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    2020-08-10 lovetcm

    #骨质疏松#与哮喘关联

    0

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    2020-08-10 lovetcm

    #哮喘#从中医角度肾不纳气,肾气虚而筋骨弱。中医补肾能解决这个问题。同时这类患者多见于重度哮喘,或者长期用激素人群。同时表现怕冷,往往无炎症诱发下哮喘

    0

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在芬兰,年轻男性的哮喘和过敏性疾病从1960年代中期开始增加很明显。增长速度在2000年代有所放缓,并可能在2020年代趋于平稳。

Int Arch Allergy Immunol:474名螨虫敏感患者中的Der P 23致敏分析

屋尘螨包括了一些过敏原组分,并能够引起常年过敏。最近,一种新的过敏原Der p 23在不同的欧洲国家具有相对较高的致敏比例。另外,Der p 23也被认为能够引起哮喘疾病。

Eur Respir J:有氧运动训练对哮喘成人的影响

在有哮喘的成年人中,有氧运动训练有可能改善哮喘控制和肺功能,但不能改善气道炎症。

欧洲药品管理局:支持诺华的Enerzair Breezhaler三联疗法治疗不受控制的哮喘

诺华制药近日宣布,欧洲药品管理局(EMA)支持Enerzair(茚达特罗/吡咯烷酮/糠酸莫米松)治疗不受控制的哮喘。