中山大学研究发现,多吃ω-3脂肪酸,可降低中国人乳腺癌风险

2022-08-08 医诺维 医诺维

这项以医院为基础的病例对照研究显示,富含Omega-3多不饱和脂肪酸的饮食可能有助于降低中国人群患乳腺癌的风险。

Omega-3,为一组多元不饱和脂肪酸,常见于大豆、坚果、菜籽油、亚麻籽等植物和深海鱼中,对人体健康十分有益。Omega-3是人体无法自行合成的脂肪酸,同时也是人体合成各种荷尔蒙及内生性物质必要的营养素,只有靠食物外来的补充这些油酸,才能让人体的生理机能得以正常运作。

乳腺癌,是女性中最常见的癌症,在神刊 CA-CANCER J CLIN 2021年癌症统计报告中显示,乳腺癌已成为女性三大癌症之首,仅乳腺癌就占女性癌症的30%。世界卫生组织国际癌症研究机构(IARC)发布的2020年全球最新癌症负担数据显示,乳腺癌新发病例数快速增长达226万,首次正式取代肺癌成为全球第一大癌症。

在中国,乳腺癌的发病率也在逐年提升。据统计,中国乳腺癌的5年生存率为82%,尽管总体生存率很高,但20%-40%的乳腺癌患者最终会复发。因此,有效预防、控制疾病和降低死亡率仍然是一个重大挑战。

近日,中山大学公共卫生学院张彩霞教授在《北美更年期协会》杂志" Menopause "上发表了一篇题为" Association of dietary intake of n-3 polyunsaturated fatty acids with breast cancer risk in pre- and postmenopausal Chinese women "的研究论文。

这项基于医院的病例对照研究发现,饮食中大量摄入Omega-3脂肪酸,可以降低中国人患乳腺癌的风险。

众所周知,饮食直接影响着人类的健康。良好的饮食习惯是健康的一个重要方面,可使身体健康地生长、发育。不良的饮食习惯则会导致人体正常的生理功能紊乱而感染疾病。越来越多的证据表明,Omega-3多不饱和脂肪酸可能在乳腺癌的发病机制中发挥作用。

在该研究中,研究人员进行了一项以医院为基础的病例对照研究,包括1589例病例和1621名年龄匹配的对照组,通过经过验证的食物频率问卷收集了参与者的膳食数据,评估了中国女性乳腺癌风险与Omega-3多不饱和脂肪酸摄入之间的关联,还检查了这种关联是否受到更年期状态、激素受体状态或摄入量的影响。

研究发现,深海鱼中的Omega-3脂肪酸和总Omega-3脂肪酸摄入量越高,患乳腺癌的风险就越低。

饮食中多不饱和脂肪酸及其亚型对乳腺癌风险的影响

此外,饮食中的α-亚麻酸、二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸也与乳腺癌风险呈负相关,这种反向关联在绝经前妇女和患有某些类型乳腺肿瘤的妇女中更为明显。

不仅如此,在超重/肥胖的女性中,乳腺癌风险的降低与Omega-3脂肪酸摄入量的增加显著相关,亚油酸与海洋Omega-3脂肪酸之间存在显著的相互作用。

在肥胖人群中,ω-3与乳腺癌的关系

研究人员表示,生活方式、饮食会导致高达30%的乳腺癌风险,项研究强调了饮食的影响,特别是多不饱和脂肪酸的饮食摄入对乳腺癌风险的影响。女性可以通过改变饮食,包括水果和蔬菜、纤维和全谷物,以及避免高脂肪动物和乳制品,来影响患乳腺癌的风险。

总之,这项以医院为基础的病例对照研究显示,富含Omega-3多不饱和脂肪酸的饮食可能有助于降低中国人群患乳腺癌的风险。

论文链接:

doi:10.1097/GME.0000000000001990

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    2023-03-26 sjq027
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    2022-08-09 calnjmu

    多重证据证实不饱和脂肪酸的价值优于饱和脂肪酸

    0

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