Pathog Dis:口腔细菌会影响肠道微生物组和肠道免疫力

2020-10-03 MedSci原创 MedSci原创

近来,有学者认为牙周病的关键病原体--牙龈卟啉菌的口服使用会诱发小鼠肠道微生物群失调,影响肠道屏障功能。由于口腔链球菌是最主要的口腔细菌群,本研究比较了口腔链球菌与牙龈卟啉单胞菌对肠道的影响,研究结果

近来,有学者认为牙周病的关键病原体--牙龈卟啉菌的口服使用会诱发小鼠肠道微生物群失调,影响肠道屏障功能。由于口腔链球菌是最主要的口腔细菌群,本研究比较了口腔链球菌与牙龈卟啉单胞菌对肠道的影响,研究结果已在线发表于Pathog Dis。

结果显示,口腔链球菌会引起肠道菌群失调,这是由于芽孢杆菌和葡萄球菌增加,以及乳酸杆菌减少所致。此外,口腔菌感染引起乳酸增加,琥珀酸和正丁酸含量减少。在小肠中,尽管Treg细胞数量未受影响,但Th17细胞的减少是口腔细菌感染的结果。此外,口腔细菌攻击增加了M1/M2巨噬细胞的比例,降低了粪便中免疫球蛋白A(IgA)抗体滴度。

 

综上所述,这些结果表明,口腔细菌引起的肠道菌群失调可能会导致Th17细胞和粪便IgA水平下降,M1/M2巨噬细胞比例增加,从而促进慢性炎症。

 

原始出处:

 

Ryoki KobayashiYasuhiro Ogawa, et al., Oral bacteria affect the gut microbiome and intestinal immunity. Pathog Dis. 2020 Apr 1;78(3):ftaa024. doi: 10.1093/femspd/ftaa024.

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    2020-10-04 146465bem06暂无昵称

    口腔微生物不容忽视

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    2020-10-03 ms3000001809864601

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