JAMA Pediatr:青少年时期心肺功能对晚年心血管功能的影响

2020-09-07 MedSci原创 MedSci原创

青少年时期的心肺功能水平与晚年心血管健康存在一定的关联

近日研究人员考察了儿童期和青少年时期心肺功能(CRF)与成年后健康之间的关系。

本次研究为系统综述及荟萃分析,收集截至2020年1月30日的相关文献,参与者基线年龄为3-18岁,身体健康,并随访至少1年。研究的主要终点为人体、肥胖以及心脏代谢相关参数。

55项研究,总计包含37563名青少年(46%为女性)。研究发现,基线CRF与体重指数(r=-0.11,I2=59.03)、腰围(r=-0.29,I2=69.42)、皮肤褶厚度(r=-0.34,I2=83.87)、肥胖(r=-0.15,I2=86.75)、总胆固醇水平(r=-0.12,I2=75.81)、高密度脂蛋白胆固醇(HDL-C)水平(r=0.11,I2 =69.06)、总胆固醇与HDL-C比值(r=-0.19, I2=67.07),甘油三酯水平(r=-0.10, I2=73.43),胰岛素抵抗稳态模型评估水平(r=-0.12,I2=68.26),空腹胰岛素水平(r=-0.07,I2=0),血管代谢(r=-0.18,I2=90.61)水平存在中等偏弱的相关性。荟萃回归分析发现,腰围(β=0.014)、皮褶厚度(β=0.006)、HDL-C水平(β=0.006)、甘油三酯水平(β=0.009)和心血管代谢风险(β=0.007)与CRF的相关性随着时间的推移而消失。CRF的变化与体重指数(r=-0.17, I2=39.65)、皮褶厚度(r=-0.36, I2=96.84)、肥胖(r=-0.21, I2=91.08)、HDL-C水平(r=0.05, I2=0)、低密度脂蛋白胆固醇水平(r=-0.06, I2=58.94)和晚年心血管代谢风险(r=-0.08, I2=69.53)之间存在中等偏弱的相关性。

研究认为,青少年时期的心肺功能水平与晚年心血管健康存在一定的关联。

原始出处:

Antonio García-Hermoso et al. Association of Cardiorespiratory Fitness Levels During Youth With Health Risk Later in Life A Systematic Review and Meta-analysis. JAMA Pediatr. August 31, 2020.

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    2021-06-18 feather89
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    2020-12-01 aids222
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    2020-09-09 Lexi

    不能占着年轻就放松警惕!

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1728654, encodeId=28211e28654a7, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Jun 18 10:26:47 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639600, encodeId=8e2616396007d, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jun 27 19:26:47 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684569, encodeId=cbef16845690b, content=<a href='/topic/show?id=dfae5133e1d' target=_blank style='color:#2F92EE;'>#心肺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51337, encryptionId=dfae5133e1d, topicName=心肺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8e128082444, createdName=aids222, createdTime=Tue Dec 01 06:26:47 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883946, encodeId=c3ae883946f0, content=不能占着年轻就放松警惕!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Wed Sep 09 18:28:40 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884130, encodeId=79bc884130fd, content=是否存在地区差异??, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Thu Sep 10 10:22:54 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372965, encodeId=88a713e29655d, content=<a href='/topic/show?id=8fab513405b' target=_blank style='color:#2F92EE;'>#心肺功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51340, encryptionId=8fab513405b, topicName=心肺功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Sep 09 10:26:47 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512008, encodeId=da2815120083f, content=<a href='/topic/show?id=da82895e077' target=_blank style='color:#2F92EE;'>#血管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89570, encryptionId=da82895e077, topicName=血管功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a8810427189, createdName=1249859em41(暂无昵称), createdTime=Wed Sep 09 10:26:47 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036260, encodeId=453e1036260ff, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Sep 07 22:26:47 CST 2020, time=2020-09-07, status=1, ipAttribution=)]
    2020-09-10 咻凡

    是否存在地区差异??

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1728654, encodeId=28211e28654a7, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Jun 18 10:26:47 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639600, encodeId=8e2616396007d, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jun 27 19:26:47 CST 2021, time=2021-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684569, encodeId=cbef16845690b, content=<a href='/topic/show?id=dfae5133e1d' target=_blank style='color:#2F92EE;'>#心肺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51337, encryptionId=dfae5133e1d, topicName=心肺)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8e128082444, createdName=aids222, createdTime=Tue Dec 01 06:26:47 CST 2020, time=2020-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883946, encodeId=c3ae883946f0, content=不能占着年轻就放松警惕!, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae205385871, createdName=Lexi, createdTime=Wed Sep 09 18:28:40 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884130, encodeId=79bc884130fd, content=是否存在地区差异??, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Thu Sep 10 10:22:54 CST 2020, time=2020-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372965, encodeId=88a713e29655d, content=<a href='/topic/show?id=8fab513405b' target=_blank style='color:#2F92EE;'>#心肺功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51340, encryptionId=8fab513405b, topicName=心肺功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Wed Sep 09 10:26:47 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512008, encodeId=da2815120083f, content=<a href='/topic/show?id=da82895e077' target=_blank style='color:#2F92EE;'>#血管功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89570, encryptionId=da82895e077, topicName=血管功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a8810427189, createdName=1249859em41(暂无昵称), createdTime=Wed Sep 09 10:26:47 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036260, encodeId=453e1036260ff, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Sep 07 22:26:47 CST 2020, time=2020-09-07, status=1, ipAttribution=)]
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    2020-09-07 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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