World Allergy Organ J:过敏性鼻炎历史和哮喘风险研究

2019-11-10 AlexYang MedSci原创

在一些研究中,过敏性鼻炎被质疑是哮喘的一个风险因子,但是该相关性并没有很好的证实。最近,有研究人员通过一个系统的回顾和元分析提出了过敏性鼻炎与哮喘风险相关性的证据。研究人员在Medline、Scopus、ISI会议记录数据库和其他数据库中进行了搜索,截止时间为2019年2月,之后进行人工检索来鉴定报道相对风险评估和过敏性鼻炎和哮喘相关性置信区间的案例对照和群体研究,研究人员排除了代表性的额研究。研

在一些研究中,过敏性鼻炎被质疑是哮喘的一个风险因子,但是该相关性并没有很好的证实。最近,有研究人员通过一个系统的回顾和元分析提出了过敏性鼻炎与哮喘风险相关性的证据。

研究人员在Medline、Scopus、ISI会议记录数据库和其他数据库中进行了搜索,截止时间为2019年2月,之后进行人工检索来鉴定报道相对风险评估和过敏性鼻炎和哮喘相关性置信区间的案例对照和群体研究,研究人员排除了代表性的额研究。研究共包括了29个符合要求的研究,其中22个群体和7个案例对照研究,总共有274489名参与者包括在了元分析中。结果表明了过敏性鼻炎的历史与哮喘的发生具有显著的相关性(OR=3.82; 95% CI: 2.92-4.99)。欧洲人群研究(OR=4.35; 95% CI: 3.12-6.06) 表现出了比非欧洲人群更强的相关性(OR=2.75; 95% CI: 2.16-3.50)。案例对照研究(OR=4.71; 95% CI: 3.58-6.17)要比群体研究(OR=3.42; 95% CI: 2.60-4.50)也表现出了更强的相关性。

最后,研究人员指出,他们的元分析表明了过敏性鼻炎与哮喘显著相关。研究人员也表明了还需要进一步的前瞻性研究来阐明过敏性鼻炎的治疗对哮喘发展的影响。另外,缓解气道过敏症状可能需要同时控制过敏性鼻炎和哮喘。

原始出处:

Tohidinik HR, Mallah N, Takkouche B et al. History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis. World Allergy Organ J. 17 Oct 2019

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    2019-11-12 膀胱癌
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    2019-11-12 cathymary

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Int Forum Allergy Rhinol:类胆碱能神经元D-U87细胞能估促进过敏性鼻炎T辅助细胞2的极化

副交感神经过敏对过敏性鼻炎(AR)的严重度是有贡献的,但是潜在的神经免疫调控的精细机制仍旧不清楚。最近,有研究人员调查了胆碱能神经抑制剂对AR CD4+ T辅助细胞2(Th2)的极化的影响以及潜在的调控机制。研究人员建立了体外D-U87细胞和CD4+ T细胞的共培养模型。研究发现,Th2细胞比例在来源于AR患者的CD4+ T细胞与D-U87细胞共培养后显著增加,但是在异丙托溴铵(IB)处理后减少。