Diabetes Care:1型糖尿病患者脂蛋白(a)与心血管疾病患病率和代谢状态的关系

2020-02-05 xing.T MedSci原创

由此可见,Lp(a)是1型糖尿病患者大血管疾病、蛋白尿和钙化主动脉瓣膜疾病的重要危险因素。1型糖尿病患者的代谢控制不佳与Lp(a)水平升高有关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在调查1型糖尿病患者的心血管危险因素脂蛋白(Lp)(a)与血管并发症之间的关系。

该观察性横断面研究招募了接受常规治疗的1型糖尿病患者,并根据其的Lp(a)水平(nmol/L)将其分为四组(极低<10、低10–30、中等30–120、高>120)。研究人员比较了两组之间的血管并发症患病率。此外,研究了代谢控制(以HbA1c衡量)与Lp(a)之间的关联。

患者(n=1860)的中位年龄为48岁,糖尿病病程为25年,HbA1c为7.8%(61 mmol/mol)。Lp(a)的中值为19(四分位数范围10-71)nmol/L。没有观察到男女之间的显著差异,但是Lp(a)的水平随着年龄的增长而增加。高脂蛋白(a)组患者的并发症发生率高于极低脂蛋白(a)组患者。经年龄和吸烟状态调整的任何大血管疾病的相对风险比值是1.51(95%CI为1.01-2.28,P=0.048);冠心病为1.70(95%CI为0.97–3.00,P=0.063);蛋白尿为1.68(95%CI为1.12–2.50,P=0.01);钙化的主动脉瓣疾病为2.03(95%CI为1.03–4.03;P=0.042)。HbA1c<6.9%(<52 mmol/mol)代谢控制良好的患者Lp(a)水平明显低于代谢控制较差HbA1c>6.9%(>52 mmol/mol)的患者。

由此可见,Lp(a)是1型糖尿病患者大血管疾病、蛋白尿和钙化主动脉瓣膜疾病的重要危险因素。1型糖尿病患者的代谢控制不佳与Lp(a)水平升高有关。

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  5. 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  6. 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  7. 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    2020-02-06 thm112988

    0

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    2020-02-05 misszhang

    谢谢MedSci提供最新的资讯

    0

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