J Mol Med:电子香烟削弱机体免疫系统

2016-02-01 QQduhp 译 MedSci原创

在美国,高中学生中使用电子烟的人数比重从2013年的4.5%到2013年的13.4%已经增长了近三倍,中学生的吸烟比重从2013年的1.1%到2014年的3.9%,超过青少年吸烟的比例。25-44岁的民众中,有20%的美国人抽电子烟。 当青少年因为时尚和潮流吸烟时,之前吸烟的烟民已经开始戒烟。有研究报道,许多青少年吸电子烟之后1年便开始吸香烟。使用电子烟增加了他们呼吸道和免疫系统受损的风险,同时也

在美国,高中学生中使用电子烟的人数比重从2013年的4.5%到2014年的13.4%已经增长了近三倍,中学生的吸烟比重从2013年的1.1%到2014年的3.9%,超过青少年吸烟的比例。25-44岁的民众中,有20%的美国人抽电子烟。 

当青少年因为时尚和潮流吸烟时,之前吸烟的烟民已经开始戒烟。有研究报道,许多青少年吸电子烟之后1年便开始吸香烟。使用电子烟增加了他们呼吸道和免疫系统受损的风险,同时也增加了他们感染的风险。
圣地亚哥加州大学(UCSD)的研究人员使用小鼠进行研究电子烟对人类的危害。他们将小鼠暴露电子烟条件下,每天1小时,每周5天,持续 4周。
 
结果表明,小鼠暴露于电子烟环境下后,它们呼吸道和血液中的炎症标记物相比未暴露于电子烟的小鼠高出10%,且暴露于香烟蒸气中的细菌导致民众罹患肺炎后更致命。
 
当正常小鼠感染耐甲氧西林金黄色葡萄球菌(MRSA)后,它们活下来了,但暴露于电子烟的小鼠中有25%感染MRSA后死亡。换句话说,金黄色葡萄球菌暴露于香烟蒸气时变得更加致命。
 
研究人员观察到,细菌病原体暴露在香烟蒸气时它们的生命力更旺盛。 蒸汽帮助金黄色葡萄球菌细菌形成生物膜,有利于它们入侵呼吸道并干扰机体正常生理活动,且可削弱人体免疫系统防御功能。且不论参与者使用何种品牌的电子烟,结果都一样。
 
加州大学圣地亚哥分校医学院的Laura E. Crotty Alexander博士认为,这项研究表明,电子烟蒸气对人类有害,大剂量香烟蒸气可直接杀死肺癌细胞。这项研究证实,每天吸入的烟蒸气会导致机体气道内的炎性环境发生变化。 

Crotty Alexander博士指出,目前尚不清楚肺癌和系统性疾病是否由吸入烟蒸气引起,但数据表明,机体炎性环境改变会出现急性毒性反应。  

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    2016-09-09 知难而进

    谢谢分享!

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    2016-09-09 知难而进

    继续关注!

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