Hypertension:夜间脉搏压力变化增加而非动态血压水平可预测血液透析患者全因死亡率

2019-08-01 xing.T MedSci原创

由此可见,在血液透析患者中,短期夜间脉压变化增加而非动态血压水平可显著预测长期全因死亡率。

短期血压(BP)变异性增加与高血压患者的心血管不良结局相关。近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究旨在调查血液透析患者短期血压变异性的长期预后意义。

该研究共纳入了149名接受常规血液透析>6个月的患者(53.0%男性;平均年龄:54.5±15.1岁)。他们完成了44小时(不包括血液透析疗程)动态血压监测和综合血液动力学评估,包括颈动脉-股动脉脉搏波速度和压力波形分解(前向和后向波振幅)。计算血压变异性参数,包括白天、夜间和总体44小时的收缩压、舒张压和脉压(ARVp)的平均实际变异性(ARV)。

在14年的中位随访期间,共确诊了78例死亡(52.4%)。在多变量Cox回归分析中,没有一个动态血压参数可以预测死亡率。相比之下,夜间ARVp与多变量Cox模型中的全因死亡率一致且显著相关,调整年龄、性别、白蛋白、血液透析治疗充分程度和44小时收缩压(连续变量分析,每1个SD的风险比=1.348; 95%CI为1.029-1.767;分类变量分析,≥8.5 vs. <8.5 mmHg;风险比=1.825; 95%CI为1.074-3.103)。前波振幅和44小时收缩压BP被确定为夜间ARVp的2个最重要决定因素。向基础模型添加夜间ARVp显著改善了全因死亡率的预测(净重分类改善=0.198; P=0.0012)。

由此可见,在血液透析患者中,短期夜间脉压变化增加而非动态血压水平可显著预测长期全因死亡率。

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  5. 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style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Aug 03 12:31:00 CST 2019, time=2019-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1509009, encodeId=4cfa150900997, content=<a href='/topic/show?id=a7c83311e88' target=_blank style='color:#2F92EE;'>#动态血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33117, encryptionId=a7c83311e88, topicName=动态血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c1e10025437, createdName=limedical1977, createdTime=Sat Aug 03 12:31:00 CST 2019, time=2019-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570649, encodeId=da5915e0649ec, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Sat Aug 03 12:31:00 CST 2019, time=2019-08-03, status=1, ipAttribution=)]
    2019-08-03 小mon

    不错

    0

  6. 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  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570649, encodeId=da5915e0649ec, content=<a href='/topic/show?id=e53d94835a5' target=_blank style='color:#2F92EE;'>#透析患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Sat Aug 03 12:31:00 CST 2019, time=2019-08-03, status=1, ipAttribution=)]
    2019-08-03 habb
  8. 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  9. 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