Clin Nutr:乳蛋白质摄入越多,非酒精性脂肪肝风险越低!

2021-09-19 Nebula MedSci原创

食用牛奶和其他乳制品有助于预防 NAFLD

非酒精性脂肪肝(NAFLD)是最常见的慢性肝病,与代谢功能障碍密切相关,包括胰岛素抵抗、肥胖和代谢综合征。全球约 25% 的人患有 NAFLD。NAFLD 的全球发病率波动在 28.0/1000人·年~52.3/1000人·年,其中东亚地区的发病率最高。

富含酪蛋白和乳清蛋白的乳蛋白有助于减少代谢性疾病。该研究旨在调查乳蛋白摄入量与 NAFLD 事件之间的相关性。

研究人员分析了来自韩国基因组和流行病学研究 (KoGES) 的 5171 名 40-69 岁成年人的数据。参与者分为男性、≥50 岁的女性和<50 岁的女性,然后根据乳蛋白摄入量再分为三等分组。NAFLD 诊断标准为 NAFLD 肝脏脂肪评分 >-0.640。绘制 Cox 比例风险样条曲线以可视化乳蛋白摄入量与 NAFLD 事件之间的剂量反应关系。

乳蛋白摄入量与不同分组受试者 NAFLD 风险的相关性

Cox 比例风险样条曲线显示,乳蛋白摄入量与 NAFLD 发生之间呈负线性关系。男性和 ≥ 50 岁的女性受试者的 NAFLD 累积发病率随着乳蛋白摄入量的三分位数增加而显著降低。根据混杂因素调整后,与最低三分位范围的个体相比,中间和最高三分位范围的男性发生 NAFLD 的风险比分别是 0.80 (95% CI 0.67–0.96) 和 0.71 (0.57–0.88);中、高三分位范围的 ≥ 50岁的女性发生 NAFLD 的风险比分别是 0.89 (0.72–1.09) 和 0.72 (0.56–0.92),< 50 岁的女性的对应风险比分别是 1.01 (0.80–1.27) 和 0.91 (0.67–1.24) 。

综上所述,该研究发现,在男性和 ≥ 50 岁的女性中,较高的乳蛋白摄入量与发生 NAFLD 的风险呈显著负相关性。简言之,食用牛奶和其他乳制品有助于预防 NAFLD

原始出处:

Lee Jun-Hyuk,Lee Hye Sun,Ahn Sang Bong et al. Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease.[J] .Clin Nutr, 2021, 40: 5252-5260. https://doi.org/10.1016/j.clnu.2021.08.012

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    2022-01-26 ms4000001212042718

    有炎性肠病和乳糖不耐受的人怎么办?

    0

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    2021-12-25 屋顶瞄爱赏月

    学习了

    0

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  8. 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    2021-09-20 ms6000001253705830

    学习

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  9. 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    2021-09-20 仁术2021

    学习了

    0

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Clin Gastroenterol Hepatol:与NAFLD患者CAD风险相关的血清生物标志物

高 hs-cTnI 水平与NAFLD 患者的 CAD 风险增加相关;hs-cTnI 或可作为 NAFLD 患者 CAD 风险预测的有用标志物

柳叶刀子刊重磅发现,脂肪肝可导致多系统疾病

非酒精性脂肪性肝病 (NAFLD) 是一种常见的疾病,是指少喝酒或不喝酒的人的肝脏中积聚过多脂肪的一组疾病。NAFLD 最常见的形式为脂肪肝。在脂肪肝中,脂肪积聚在肝细胞中.