JAHA：血清尿酸累积量及其时间变化与心肌梗死和全因死亡率相关

2021-06-14 MedSci原创 MedSci原创

MI的风险和全因死亡率随着cumSUA的增加而增加，并受SUA积累时间过程的影响。在总体累积暴露相同的情况下，早期SUA积累比后期SUA积累对MI风险和全因死亡率的贡献更大。

血清尿酸(SUA)已被证明是心肌梗死(MI)和全因死亡的危险因素；然而，累积SUA(cumSUA)对MI和全因死亡的效应尚未明确。

近日，心血管疾病领域权威杂志JAHA上发表了一篇研究文章，研究人员旨在调查cumSUA与MI风险和全因死亡率之间的关系，并进一步探讨SUA积累的时间效应。

该研究招募了53463名无MI病史的参与者，这些参与者在2006年至2010年间接受了3次检查。研究人员计算了受试者从基线到第3次检查的cumSUA，并将连续检查的平均值乘以两次就诊的时间间隔。Cox模型估计了根据cumSUA四分位数、高尿酸血症暴露时间和SUA积累时间过程导致的MI和全因死亡率的危险比(HRs)和95%CI。

心肌梗死和全因死亡率

在7.04年的中位随访期间，共发生了476例MI事件和2692例死亡病例。在完全调整的模型中，在cumSUA最高四分位数的参与者(HR为1.48；95%CI为1.10-1.99)、高尿酸血症暴露时间较长的参与者(HR为1.71；95%CI为1.06-2.73)以及cumSUA≥中位数且斜率为负的参与者(HR为1.58；95%CI为1.18-2.11)中观察到更高的MI风险。对于全因死亡率也观察到了类似的关联。

由此可见，MI的风险和全因死亡率随着cumSUA的增加而增加，并受SUA积累时间过程的影响。在总体累积暴露相同的情况下，早期SUA积累比后期SUA积累对MI风险和全因死亡率的贡献更大，这强调了在生命早期对SUA进行控制的重要性。

原始出处：

Xue Tian.et al.Cumulative Serum Uric Acid and Its Time Course Are Associated With Risk of Myocardial Infarction and All‐Cause Mortality.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.020180

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2021-06-16 lvliquan

#全因死亡率#

32 0
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2021-06-16 zhaohui6731

#AHA#

31 0
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2021-06-16 feifers

#血清尿酸#

32 0
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2021-06-15 ms7000002130458668

认真学习。

61 0
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2021-06-15 1881ef655dm

很棒啊

68 0
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2021-06-15 smart Ren

认真学习

58 0
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2021-06-14 言西早

血清尿酸(SUA)已被证明是心肌梗死(MI)和全因死亡的危险因素。

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