Clinical Nutrition: 妊娠前三个月维生素D状况与妊娠糖尿病之间的关系

2021-01-19 MedSci原创 MedSci原创

妊娠期糖尿病(GDM)是怀孕期间最常见的并发症之一。从长远来看,它与许多不良妊娠,胎儿和新生儿结局以及母亲和儿童的风险增加有关。人们对维生素D及其在代谢性疾病发展中的潜在作用越来越感兴趣。

背景与目标:

妊娠期糖尿病(GDM)是怀孕期间最常见的并发症之一。从长远来看,它与许多不良妊娠,胎儿和新生儿结局以及母亲和儿童的风险增加有关。人们对维生素D及其在代谢性疾病发展中的潜在作用越来越感兴趣。但是,医学文献尚未达成共识。这项研究的目的是根据孕早期的维生素D状况评估GDM的风险。

方法:

这项研究是一项病例对照研究,所有进行25-OH维生素D水平(25OHD)检测的孕妇组成了本项研究的研究对象,总共包括1191名孕妇。将250例患有GDM的妇女(病例)与941例没有GDM的妇女(对照组)进行配对,以确认其胎次,年龄,怀孕前的体重指数,受孕的季节在比较时不存在差异。

结果:

25OHD水平<20 ng / mL的患者,GDM的风险明显更高(OR = 1∙42,95%CI 1∙06–1∙91; p = 0∙021)。但是,与其他变量没有显着关系。对25OHD水平以5个单位间隔进行更精确切割显示出与GDM风险的可变关系:非常低的25OHD水平的发生GDM的风险低,中等水平25OHD则会导致GDM发生风险增加。

结论

妊娠前三个月GDM与25OHD水平之间似乎有线性关系,因为随着25OHD浓度增加,GDM风险会持续降低。

原始出处:

Eleonora Salakos. Et al. Relationship between vitamin D status in the first trimester of pregnancy and gestational diabetes mellitus - A nested case–control study. Clinical Nutrition.2021.

 

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    2021-01-21 zll0628
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    2021-01-19 lifefamily

    #妊娠糖尿病#事实上,仅仅补充#维生素D#想见效,并不容易吧

    0

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    2021-01-19 misszhang

    谢谢MedSci提供最新的资讯

    0

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