Int Arch Allergy Immunol:肥胖可导致儿童重度持续性过敏性鼻炎

2021-03-26 AlexYang MedSci原创

肥胖/超重与儿童更高的过敏性鼻炎(AR)风险有关。

肥胖/超重与儿童更高的过敏性鼻炎(AR)风险有关

最近,有研究人员探索了肥胖通过瘦素和白细胞介素(IL)-1β影响AR严重度的机制。

研究共包括了210名AR患者和82名非AR患者,测定了血清中瘦素和炎症生物标志物的水平来调查与AR严重程度的相关性。此外,研究人员通过对肥胖儿童的连续随访,分析了BMI的变化是否会调节AR的严重程度。结果发现,IL-1β是AR活动性炎症的生物标志物,AR患者的IL-1β显著高于非AR者,且肥胖组受试者的IL-1β高于正常体重组。回归分析显示,瘦素水平与AR患儿IL-1β表达增加有关。在多变量分析中,只有父母AR(风险增加9.2倍)、瘦素升高(风险增加11.3倍)、IL-1β高表达(风险增加5.8倍)是中度至重度持续性过敏性鼻炎的重要风险因素。研究人员还发现,BMI增加或减少的儿童表现出了IL-1β和AR症状的变化,且这些变化依赖于瘦素和BMI。

最后,研究人员指出,肥胖是AR症状加重的重要风险因素,瘦素可以通过AR中的IL-1β加重炎症和严重的持续性症状

原始出处:

Myung Woul Han , Song Hee Kim , Inbo Oh et al. Obesity Can Contribute to Severe Persistent Allergic Rhinitis in Children through Leptin and Interleukin-1β. Int Arch Allergy Immunol. Mar 2021

 

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    2021-03-28 膀胱癌
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    2021-03-27 1436749007

    学习到了很多东西谢谢老师

    0

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    2021-03-26 jyzxjiangqin

    好文章!

    0

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