Eur Urol:有无放疗的雄激素阻断治疗原发性转移前列腺癌患者的生活质量

2020-10-20 AlexYang MedSci原创

在雄激素阻断治疗(ADT)的基础上加上局部放疗,能够对低体积转移性前列腺癌(mPCa)患者的生存有益。最近,有研究人员确定了ADT联用前列腺体外放疗(EBRT)对原发性骨mPCa患者的健康相关生活质量

在雄激素阻断治疗(ADT)的基础上加上局部放疗,能够对低体积转移性前列腺癌(mPCa)患者的生存有益。最近,有研究人员确定了ADT联用前列腺体外放疗(EBRT)对原发性骨mPCa患者的健康相关生活质量(HRQoL)的影响。

HORRAD试验是一项多中心随机对照试验,包括了432名原发性骨mPCa患者,时间为2004年至2014年之间。研究包括了ADT联用EBRT和只单独使用ADT两个组。研究发现,两组患者基线时的特征和HRQoL评分相似。基线时,98%的患者完成了问卷调查,而24个月时为58%。与单独使用ADT相比,EBRT和ADT联用患者报告的腹泻(组间差异为10.8;95%CI 7.3-14.2)、肠道症状(4.5;95%CI 2.1-6.8)和泌尿系统症状(11.9;95%CI 8.9-14.8)明显增多(所有组间差异P<0.001)。泌尿系统症状在6第6个月时趋于平稳。在第2年时,只有肠道症状评分有显著差异(8.0;95%CI 4.8-11.1,p≤0.001),但放疗组68%的患者没有报告临床相关的肠道症状评分恶化。

在基线和第3,6,12和24个月时EORTC C-30和PR-25调查问卷的HRQoL评分

最后,研究人员指出,与单独使用ADT相比,骨性mPCa患者在前列腺EBRT和ADT联合治疗后,报告了暂时性温和的泌尿和肠道症状。对于部分患者(22%),2年后肠道功能仍有恶化,而HRQoL没有发生恶化。

原始出处:

Liselotte Boevé , Maarten C C M Hulshof , Paul C M S Verhagen et al. Patient-reported Quality of Life in Patients with Primary Metastatic Prostate Cancer Treated with Androgen Deprivation Therapy with and Without Concurrent Radiation Therapy to the Prostate in a Prospective Randomised Clinical Trial; Data from the HORRAD Trial. Eur Urol. Sep 2020

 

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    2020-10-25 ms3000000449926787

    学习了

    0

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    2020-10-22 gaohar17

    学习学习

    0

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    2020-10-20 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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    2020-10-20 liyu7822

    呵呵

    0

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