Clin Oral Investig:二极管激光是治疗白塞氏病相关口腔溃疡的高效安全治疗方式

2022-02-22 MedSci原创 MedSci原创

白塞氏病表现为复发性口腔溃疡、生殖器溃疡和虹膜炎三联症,是一种慢性、复发性、多系统的炎症性疾病。药物局部治疗通常被用作口腔溃疡的一线治疗,近些年激光成为口腔溃疡及相关病变的一种安全的替代治疗方式。

白塞氏病表现为复发性口腔溃疡、生殖器溃疡和虹膜炎三联症,是一种慢性、复发性、多系统的炎症性疾病。药物局部治疗通常被用作口腔溃疡的一线治疗,近些年激光成为口腔溃疡及相关病变的一种安全的替代治疗方式。近日,发表于Clin Oral Investig的一项随机试验评估了二极管激光治疗与局部皮质类固醇相比在治疗白塞氏病相关口腔溃疡方面的效果。

研究共纳入了50名白塞氏病患者,随机分为两个平行组:第一组接受980纳米的二极管激光治疗;第二组接受局部皮质类固醇(0.1%曲安奈德)治疗。评估结果包括口腔溃疡活动指数(综合指数)、疼痛(VAS)、口腔溃疡的数量、愈合时间和口腔健康相关的生活质量(OHIP-14)。

结果显示,激光组和皮质类固醇组之间在第一天和第三天的综合指数和VAS评分以及第三天和第五天的溃疡数量方面没有显著的统计学差异,但均较基线有显著改善。但是,在第一天和/或第三天的进食不适、烦躁、味道变差、饮食满意度和疼痛评分方面,激光组显著优于皮质类固醇组,差异有统计学意义。所有患者在完全愈合后进行了随访,直到本时间段结束,没有复发的报告。两组的参与者都没有报告不良反应。

综上所述,该研究结果表明,二极管激光是治疗白塞氏病相关口腔溃疡的高效安全治疗方式。二极管激光在控制疼痛和减少口腔溃疡活动方面比曲安奈德更有效。

原始出处:

Clair Sobhy Nagieb, et al., Evaluation of diode laser versus topical corticosteroid in management of Behcet's disease-associated oral ulcers: a randomized clinical trial. Clin Oral Investig. 2022 Jan;26(1):697-704. doi: 10.1007/s00784-021-04047-8.

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    2022-04-26 小几洁
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    2023-01-07 howi
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2020694, encodeId=232a2020694d9, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Tue Apr 26 05:50:58 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975811, encodeId=e0ce19e5811fe, content=<a href='/topic/show?id=fdbc6464eb2' target=_blank style='color:#2F92EE;'>#治疗方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64647, encryptionId=fdbc6464eb2, topicName=治疗方式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Jan 07 20:50:58 CST 2023, time=2023-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051758, encodeId=f74f2051e58ed, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Thu Mar 31 03:50:58 CST 2022, time=2022-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822295, encodeId=5aba182229557, content=<a href='/topic/show?id=ce6810239e92' target=_blank style='color:#2F92EE;'>#高效安全#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102397, encryptionId=ce6810239e92, topicName=高效安全)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c66088, createdName=gao_jian4217, createdTime=Tue Aug 16 16:50:58 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989657, encodeId=0ce4198965efd, content=<a href='/topic/show?id=541c239345a' target=_blank style='color:#2F92EE;'>#二极管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23934, encryptionId=541c239345a, topicName=二极管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Thu Jan 05 19:50:58 CST 2023, time=2023-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279814, encodeId=4aea12e981496, content=<a href='/topic/show?id=265c66e50ea' target=_blank style='color:#2F92EE;'>#激光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Wed Feb 23 13:50:58 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196108, encodeId=237e1196108de, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ede65630636, createdName=ms2000001545439177, createdTime=Tue Feb 22 16:24:16 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196045, encodeId=b69811960454f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9be6495931, createdName=ms8000000018254969, createdTime=Tue Feb 22 13:06:24 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196034, encodeId=f40f11960341f, content=好文章,共享之。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Tue Feb 22 12:42:34 CST 2022, time=2022-02-22, status=1, ipAttribution=)]
    2022-02-23 oliver169
  7. [GetPortalCommentsPageByObjectIdResponse(id=2020694, encodeId=232a2020694d9, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Tue Apr 26 05:50:58 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975811, encodeId=e0ce19e5811fe, content=<a href='/topic/show?id=fdbc6464eb2' target=_blank style='color:#2F92EE;'>#治疗方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64647, encryptionId=fdbc6464eb2, topicName=治疗方式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Jan 07 20:50:58 CST 2023, time=2023-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051758, encodeId=f74f2051e58ed, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Thu Mar 31 03:50:58 CST 2022, time=2022-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822295, encodeId=5aba182229557, content=<a href='/topic/show?id=ce6810239e92' target=_blank style='color:#2F92EE;'>#高效安全#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102397, encryptionId=ce6810239e92, topicName=高效安全)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c66088, createdName=gao_jian4217, createdTime=Tue Aug 16 16:50:58 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989657, encodeId=0ce4198965efd, content=<a href='/topic/show?id=541c239345a' target=_blank style='color:#2F92EE;'>#二极管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23934, encryptionId=541c239345a, topicName=二极管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Thu Jan 05 19:50:58 CST 2023, time=2023-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279814, encodeId=4aea12e981496, content=<a href='/topic/show?id=265c66e50ea' target=_blank style='color:#2F92EE;'>#激光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Wed Feb 23 13:50:58 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196108, encodeId=237e1196108de, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ede65630636, createdName=ms2000001545439177, createdTime=Tue Feb 22 16:24:16 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196045, encodeId=b69811960454f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9be6495931, createdName=ms8000000018254969, createdTime=Tue Feb 22 13:06:24 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196034, encodeId=f40f11960341f, content=好文章,共享之。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Tue Feb 22 12:42:34 CST 2022, time=2022-02-22, status=1, ipAttribution=)]
    2022-02-22 ms2000001545439177

    受益匪浅

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2020694, encodeId=232a2020694d9, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Tue Apr 26 05:50:58 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975811, encodeId=e0ce19e5811fe, content=<a href='/topic/show?id=fdbc6464eb2' target=_blank style='color:#2F92EE;'>#治疗方式#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64647, encryptionId=fdbc6464eb2, topicName=治疗方式)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Jan 07 20:50:58 CST 2023, time=2023-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2051758, encodeId=f74f2051e58ed, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Thu Mar 31 03:50:58 CST 2022, time=2022-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822295, encodeId=5aba182229557, content=<a href='/topic/show?id=ce6810239e92' target=_blank style='color:#2F92EE;'>#高效安全#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102397, encryptionId=ce6810239e92, topicName=高效安全)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c66088, createdName=gao_jian4217, createdTime=Tue Aug 16 16:50:58 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989657, encodeId=0ce4198965efd, content=<a href='/topic/show?id=541c239345a' target=_blank style='color:#2F92EE;'>#二极管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23934, encryptionId=541c239345a, topicName=二极管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e183245, createdName=Eleven11, createdTime=Thu Jan 05 19:50:58 CST 2023, time=2023-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279814, encodeId=4aea12e981496, content=<a href='/topic/show?id=265c66e50ea' target=_blank style='color:#2F92EE;'>#激光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Wed Feb 23 13:50:58 CST 2022, time=2022-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196108, encodeId=237e1196108de, content=受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ede65630636, createdName=ms2000001545439177, createdTime=Tue Feb 22 16:24:16 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196045, encodeId=b69811960454f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9be6495931, createdName=ms8000000018254969, createdTime=Tue Feb 22 13:06:24 CST 2022, time=2022-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1196034, encodeId=f40f11960341f, content=好文章,共享之。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Tue Feb 22 12:42:34 CST 2022, time=2022-02-22, status=1, ipAttribution=)]
    2022-02-22 ms8000000018254969

    学习

    0

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    2022-02-22 yangchou

    好文章,共享之。

    0

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