Marine Drugs:红海藻抗癌机制被发现?

2021-06-15 MedSci原创 MedSci原创

数千年来,红海藻一直在亚洲饮食中盛行。尽管多项研究表明,经常食用海藻的亚洲人患结肠癌、结直肠癌和乳腺癌的风险较低,但尚不清楚哪种成分具有抗癌作用。

数千年来,红海藻一直在亚洲饮食中盛行。尽管多项研究表明,经常食用海藻的亚洲人患结肠癌结直肠癌乳腺癌的风险较低,但尚不清楚哪种成分具有抗癌作用。

近日,发表在Marine Drugs 上的一项新研究揭示了红海藻对机体健康带来益处。在这项研究中,研究人员使用酶分解了不同类型红海藻的结构,并测试了分解出来的糖分,来探索其对健康的益处。在分解产生的六种不同的糖中,琼脂三糖 (AgaDP3) 3,6-脱水-L-半乳糖或 AHG 表现出很大的希望。通过长双歧杆菌 ssp. infantis 测试了它们的益生元活性。结果显示,琼脂三糖 (AgaDP3) 表现出益生元活性,促进益生菌的生长。

红海藻含有糖类,可刺激益生元细菌的生长并导致人类结肠癌细胞凋亡.

同时,研究人员还进行了另一种菌株 B. kashiwanohense对分解出来的糖分进行验证,发现同样能消耗琼脂三糖 (AgaDP3)

研究人员表示,这些结果表明,当人们在吃红海藻时,它会在肠道中分解并释放出琼脂糖,这些琼脂糖可以作为益生菌的食物。这有助于解释为什么日本人比其他人更健康。

研究人员进一步测试了分解出来的糖分的抗癌活性,发现AHG能够触发细胞凋亡或细胞死亡,且 特异性抑制人类结肠癌细胞的生长,而不影响正常细胞的生长。

研究人员表示,关于红海藻如何被海洋和人体中的微生物降解的研究有很多,我们通过分子机制解释了为什么红海藻对人体健康有益。未来,我们将继续研究红海藻在动物模型中的功能,希望将来能够将其进行临床转化,进而加入到治疗方案中。

原始出处

Eun Yun et al, In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds, Marine Drugs (2021). DOI: 10.3390/md19040213

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1784778, encodeId=67661e8477850, content=<a href='/topic/show?id=e451626993' target=_blank style='color:#2F92EE;'>#drugs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6269, encryptionId=e451626993, topicName=drugs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dcaa509, createdName=tsing_hit, createdTime=Mon Sep 27 19:58:31 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862351, encodeId=47d8186235155, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Fri Oct 08 13:58:31 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039424, encodeId=fa861039424a3, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Tue Jun 15 22:58:31 CST 2021, time=2021-06-15, status=1, ipAttribution=)]
    2021-09-27 tsing_hit
  2. [GetPortalCommentsPageByObjectIdResponse(id=1784778, encodeId=67661e8477850, content=<a href='/topic/show?id=e451626993' target=_blank style='color:#2F92EE;'>#drugs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6269, encryptionId=e451626993, topicName=drugs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dcaa509, createdName=tsing_hit, createdTime=Mon Sep 27 19:58:31 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862351, encodeId=47d8186235155, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Fri Oct 08 13:58:31 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039424, encodeId=fa861039424a3, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Tue Jun 15 22:58:31 CST 2021, time=2021-06-15, status=1, ipAttribution=)]
    2021-10-08 wangbingxhy
  3. [GetPortalCommentsPageByObjectIdResponse(id=1784778, encodeId=67661e8477850, content=<a href='/topic/show?id=e451626993' target=_blank style='color:#2F92EE;'>#drugs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6269, encryptionId=e451626993, topicName=drugs)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dcaa509, createdName=tsing_hit, createdTime=Mon Sep 27 19:58:31 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1862351, encodeId=47d8186235155, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Fri Oct 08 13:58:31 CST 2021, time=2021-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039424, encodeId=fa861039424a3, content=机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Tue Jun 15 22:58:31 CST 2021, time=2021-06-15, status=1, ipAttribution=)]
    2021-06-15 肿肿

    机制研究离临床仍然有距离,不过与临床结合思考,仍然有帮助的,不能仅仅是纯临床思维,转化思维同样重要

    0