JAHA:ST段抬高心肌梗死患者在住院死亡率上仍存在男女不平等!

2016-11-28 haofan MedSci原创

尽管ST段抬高心肌梗死患者在治疗方面发生了从溶栓治疗向经皮冠状动脉介入治疗的全国性转变,并且这一转变影响所有年龄的男性和女性患者,但是不考虑年龄因素,女性患者的住院死亡率仍要高于男性。

ST段抬高型心肌梗死患者在治疗和预后方面存在年龄和性别特异性差异,近日,心血管病领域权威杂志JAHA上发表了来自意大利罗马圣乔凡尼伊万格丽斯塔医院心内科的Leonardo De Luca医生及其研究团队的文章,旨在对年龄和性别相匹配的ST段抬高型心肌梗死患者住院治疗和预后的当前趋势进行描述。

研究人员所使用的分析数据,来自于5个意大利全国前瞻性登记中心,在2001年至2014期间连续就诊的ST段抬高心肌梗死患者。研究人员对所有的分析对象都进行了年龄和性别匹配,并根据年龄分为4个组:<55岁组,55-64岁组,65-74岁组和≥75岁组。该研究共纳入了13,235例ST段抬高型心肌梗死患者(72.1%为男性和27.9%为女性)。

研究者发现,随着时间的推移出现了一个从溶栓治疗到主要经皮冠状动脉介入治疗渐进性转变,伴随着整体再灌注率的增加(P趋势<0.0001),这一变化在横跨性别组和各个年龄组是一致的。粗略住院死亡率在男性和女性患者中分别为3.2%和8.4%(P<0.0001),在男性和女性患者中,粗略住院死亡率随着年龄分层显著增加,但随着时间推移而显著减少(所有P趋势<0.01)。在多变量分析中,调整了其他危险因素后,研究人员发现年龄(比值比为1.09,95%可信区间为1.07–1.10,P<0.0001)和女性(比值比为1.44,95%可信区间为1.07–1.93,P=0.009)与住院死亡率显著相关,但这两个变量之间的交互作用并无统计学差异(P交互作用=0.61)。

由此可见,尽管ST段抬高心肌梗死患者在治疗方面发生了从溶栓治疗向经皮冠状动脉介入治疗的全国性转变,并且这一转变影响所有年龄的男性和女性患者,但是不考虑年龄因素,女性患者的住院死亡率仍要高于男性。

原始出处:

Leonardo De Luca,et al. Contemporary Trends and Age‐Specific Sex Differences in Management and Outcome for Patients With ST‐Segment Elevation Myocardial Infarction. JAHA.November 23, 2016.

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    2017-01-03 1e10c84am36(暂无匿称)

    文章真好,已拜读

    0

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    2016-12-06 李东泽

    很好,不错,以后会多学习

    0

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    2016-11-30 gospel007

    与抽烟,饮酒等高危因素有关。

    0

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    2016-11-30 zhaohui6731
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    2016-11-30 gdsun
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    2016-11-30 hyf035

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