JAMA Psychiatry:炎症因子还能反映心理困扰情况

2016-10-05 Mechront 译 MedSci原创

超敏C反应蛋白水平与心理困扰的18大症状有关;校正吸烟、饮酒、体重指数与慢性疾病等混杂因素后,绝大多数联系仍存在。 来自韩国汉城成均馆大学学校的Woojae Myung博士为了探讨超敏C反应蛋白与一般心理困扰症状水平之间的关联,对韩国基因组流行病学研究中的城市(n = 144312)和农村(n = 6711)数据、以及三星医疗中心参加体检(n = 63014)的个体数据,进行了分析。研究对象

超敏C反应蛋白水平与心理困扰的18大症状有关;校正吸烟、饮酒、体重指数与慢性疾病等混杂因素后,绝大多数联系仍存在。

来自韩国汉城成均馆大学学校的Woojae Myung博士为了探讨超敏C反应蛋白与一般心理困扰症状水平之间的关联,对韩国基因组流行病学研究中的城市(n = 144312)和农村(n = 6711)数据、以及三星医疗中心参加体检(n = 63014)的个体数据,进行了分析。研究对象包括214037名平均年龄为52.3岁的朝鲜族参与者。

调整年龄和性别后,所有一般的心理困扰症状与超敏C反应蛋白水平呈正相关。

调整吸烟、饮酒、体重指数与慢性疾病后,开始新工作的能力与超敏C反应蛋白水平之间不再具有统计学意义的联系(OR = 1.008; 95% CI, 0.998-1.017)。

调整年龄、性别、其他症状总和后,只有7项症状与高敏C反应蛋白水平呈正相关,包括幸福和健康的感觉(OR = 1.08; 95% CI, 1.07-1.09)、睡觉后感觉神清气爽(OR = 1.04; 95%CI, 1.03-1.06)、因为担心而失眠(OR = 1.03; 95%CI, 1.01-1.04)、集中精力的能力(OR = 1.02; 95% CI, 1-1.03)、自我管理(OR = 1.11; 95% CI, 1.05-1.17)、烦躁不安脾气暴躁(OR = 1.03; 95% CI, 1.01-1.05)、失去自信(OR = 1.03; 95%CI, 1.01-1.05)。

此外,开始新的工作能力(OR = 0.96; 95% CI, 0.95-0.97)和面对问题的能力(OR = 0.97; 95% CI, 0.96-0.98)与高敏C反应蛋白水平呈负相关。

调整所有其他变量后,只有6个项目仍与高敏C反应蛋白呈正相关,包括幸福和健康的感觉(OR = 1.07; 95% CI, 1.05-1.09)、睡觉后感觉神清气爽(OR = 1.04; 95% CI, 1.02-1.06)、因为担心而失眠(OR = 1.02; 95% CI, 1-1.04)、自我管理(OR = 1.1; 95% CI, 1.05-1.16)、烦躁不安脾气暴躁(OR = 1.02; 95% CI, 1-1.04)、丧失自信(OR = 1.03; 95% CI, 1.01-1.05)。

原始出处:

Inflammation may be associated with broader range of psychological distress.Helaio.October 4, 2016

Myung W, et al. Association Between Levels of High-Sensitivity C-Reactive Protein and General Psychological Distress Symptoms.JAMA Psychiatry. 2016;doi:10.1001/jamapsychiatry.2016.2167.

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content=超敏C反应蛋白水平与心理困扰的18大症状有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:50:54 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140534, encodeId=d252140534c6, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Oct 05 20:05:14 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140530, encodeId=f12a14053048, content=炎症对肿瘤的发病起很大作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce8c1961256, createdName=yongyuanaiping, createdTime=Wed Oct 05 19:58:33 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-19 ylzr123

    拜读了,受益匪浅,点个赞!没想到心理困扰症状还和超敏C反应蛋白水平呈正相关!

    0

  4. 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    2016-10-12 1e10c84am36(暂无匿称)

    好文章,受益

    0

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    2016-10-06 医路开来

    謝謝分享,,,

    0

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content=超敏C反应蛋白水平与心理困扰的18大症状有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:50:54 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140534, encodeId=d252140534c6, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Oct 05 20:05:14 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140530, encodeId=f12a14053048, content=炎症对肿瘤的发病起很大作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce8c1961256, createdName=yongyuanaiping, createdTime=Wed Oct 05 19:58:33 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-06 医路开来

    學習啦,,,

    0

  7. 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content=超敏C反应蛋白水平与心理困扰的18大症状有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:50:54 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140534, encodeId=d252140534c6, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Oct 05 20:05:14 CST 2016, time=2016-10-05, status=1, 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    2016-10-06 医路开来

    一般的心理困扰症状与超敏C反应蛋白水平呈正相关。

    0

  8. 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    2016-10-06 医路开来

    超敏C反应蛋白水平与心理困扰的18大症状有关

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Oct 12 09:39:48 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140850, encodeId=a0a114085081, content=謝謝分享,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:51:44 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140849, encodeId=a946140849a1, content=學習啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:51:21 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140848, encodeId=9aeb14084887, content=一般的心理困扰症状与超敏C反应蛋白水平呈正相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:51:12 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140847, encodeId=c04d14084e64, content=超敏C反应蛋白水平与心理困扰的18大症状有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:50:54 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140534, encodeId=d252140534c6, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Oct 05 20:05:14 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140530, encodeId=f12a14053048, content=炎症对肿瘤的发病起很大作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce8c1961256, createdName=yongyuanaiping, createdTime=Wed Oct 05 19:58:33 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 榄枷檬

    继续关注

    0

  10. 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createdBy=c192448, createdName=diushouji, createdTime=Tue Nov 15 21:33:00 CST 2016, time=2016-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=149749, encodeId=db95149e492a, content=拜读了,受益匪浅,点个赞!没想到心理困扰症状还和超敏C反应蛋白水平呈正相关!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Oct 19 15:23:50 CST 2016, time=2016-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=146364, encodeId=3c76146364ed, content=好文章,受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Oct 12 09:39:48 CST 2016, time=2016-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140850, encodeId=a0a114085081, content=謝謝分享,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:51:44 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140849, encodeId=a946140849a1, content=學習啦,,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:51:21 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140848, encodeId=9aeb14084887, content=一般的心理困扰症状与超敏C反应蛋白水平呈正相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:51:12 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140847, encodeId=c04d14084e64, content=超敏C反应蛋白水平与心理困扰的18大症状有关, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Thu Oct 06 11:50:54 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140534, encodeId=d252140534c6, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Oct 05 20:05:14 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140530, encodeId=f12a14053048, content=炎症对肿瘤的发病起很大作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce8c1961256, createdName=yongyuanaiping, createdTime=Wed Oct 05 19:58:33 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 yongyuanaiping

    炎症对肿瘤的发病起很大作用

    0