NEJM:BNT162b2和mRNA-1273疫苗预防新冠肺炎真实世界研究数据喜人

2021-07-25 MedSci原创 MedSci原创

BNT162b2和mRNA-1273,这2款RNA疫苗预防新冠肺炎的效果显著,即使在接种后仍不幸感染,患者的病毒载和症状风险显著降低,病程缩短

在III期临床研究中,2款RNA疫苗BNT162b2和mRNA-1273对新冠肺炎表现出良好的预防效果。在疫苗大面积接种后,这2款疫苗在现实条件中预防有症状和无症状的新冠肺炎感染的有效性与临床试验相当。近日研究人员考察了在真实世界中,2款RNA疫苗对降低感染后症状风险,降低病毒载量以及缩短检测阳性时间的效果

本次前瞻性队列研究包含3975名健康参与者,在2020年12月14日至2021年4月10日参与者每周进行鼻拭子核酸检测,以评估疫苗的预防效果。

研究期间,204名参与者核酸检测呈阳性(5%),其中5人完成接种(2剂疫苗接种且超过14天),11人部分完成接种(完成第1次接种后14天,但第2次接种后时间少于14天),156人未接种疫苗。在完成疫苗接种后,疫苗的有效率为91%,完成部分接种后为81%。在核酸阳性人群中,相比于未接种人群,部分或完成疫苗接种人群,平均病毒载量降低40%,出现发热症状的风险降低58%,卧床时间缩短2.3天。

真实世界研究显示,BNT162b2和mRNA-1273,这2款RNA疫苗预防新冠肺炎的效果显著,即使在接种后仍不幸感染,患者的病毒载和症状风险显著降低,病程缩短

原始出处:

Mark G. Thompson et al. Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines. N Engl J Med,July 22,2021.

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    2021-07-25 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2021-07-25 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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