JACC:慢性肾脏疾病可增加主动脉狭窄风险!

2019-01-25 MedSci MedSci原创

慢性肾脏疾病(CKD)和主动脉狭窄(AS)有许多共同的危险因素。本研究的目的旨在评估肾功能不全是否与AS的发展相关。本研究纳入了SCREAM 研究中的1121875名无AS诊断的城市居民,平均年龄为50岁(IQR:36-64岁),女性占54%,平均估计肾小球滤过率(eGFR)为96 ml/min/1.73 m2 (IQR:82 - 109 ml/min/1.73 m2),有66949名(6%)对象

慢性肾脏疾病(CKD)和主动脉狭窄(AS)有许多共同的危险因素。本研究的目的旨在评估肾功能不全是否与AS的发展相关。


本研究纳入了SCREAM 研究中的1121875名无AS诊断的城市居民,平均年龄为50岁(IQR:36-64岁),女性占54%,平均估计肾小球滤过率(eGFR)为96 ml/min/1.73 m2 (IQR:82 - 109 ml/min/1.73 m2),有66949名(6%)对象有慢性肾脏疾病(eGFR <60 ml/min/1.73 m2)。经过平均5.1年时间的随访,有5858名居民发展为AS(1.13/1000人年)。与 eGFR >90的居民相比,低eGFR居民的AS发病风险更高,敏感性分析只稍微减弱了两者关联的程度。


研究结果显示,慢性肾脏疾病,即使是处于中度向重度转变的时期,也与主动脉狭窄呈独立相关性。

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    2019-01-28 hbwxf
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