Eur Arch Otorhinolaryngol:慢性肾脏疾病中红细胞分布宽度与听力损伤相关

2020-04-10 AlexYang MedSci原创

之前的研究表明,在患有炎症疾病的患者中,炎症标记与听力损伤相关。因此,对炎症情况的筛查对患有炎症参与者听力损失(HL)风险的预测是有价值的。因此,有研究人员使用了炎症状态间接预测因子-红细胞分布宽度(

之前的研究表明,在患有炎症疾病的患者中,炎症标记与听力损伤相关。因此,对炎症情况的筛查对患有炎症参与者听力损失(HL)风险的预测是有价值的。因此,有研究人员使用了炎症状态间接预测因子-红细胞分布宽度(RDW),调查了韩国慢性肾脏疾病(CKD)人群中,RDW与听力损伤之间的相关性。

研究是一个代表性的研究,共包括了461名肾小球滤过率(eGFR)?<?60 ml/min/1.73 m2的参与者,并根据RDW值将参与者分成低三分位(172)、中三分位(154)和高三分位(135)。在0.5、1、2 kHz时的阈值平均值为Low/Mid-Freq,而3、4、6 kHz时的阈值取平均值为High-Freq。平均听力阈值(AHT)为0.5、1、2、3kHz时阈值的纯音均值。HL定义为AHT> 40 dB。研究发现,HL中RDW和hs-CRP的AUROCs值分别为0.644和0.522。多变量分析中,Low/Mid-Freq、High-Freq和AHT值在低三分位组中为最低。多变量逻辑回归分析表明高三分位组参与者的HL几率要比低和中三分位组参与者分别高2.32倍和1.78倍。RDW和AHT值之间存在正相关关系。

最后,研究人员指出,在韩国CKD人群中,高RDW值与听力损伤的增加是有关的。

原始出处:

Jung DJ, Yoo MH, Lee KY et al. Red cell distribution width is associated with hearing impairment in chronic kidney disease population: a retrospective cross-sectional study. Eur Arch Otorhinolaryngol. 19 Mar 2020.

 

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    2020-04-12 ysjykql
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PNAS:基因编辑在肾脏疾病中的应用

科学家首次确定了如何阻止先天性肾脏疾病,这可能为今后的个性化治疗铺平道路。 英国纽卡斯尔大学的研究人员在细胞和小鼠模型中表明,基因编辑可用于Joubert综合征,以阻止携带CEP290缺陷基因对患者肾脏造成损害。Joubert综合征是一种脑部疾病,引起不同程度的身体、精神和视觉障碍。大约80000个新生儿中有一个会得这种病,其中的三分之一患者会导致肾衰竭。

2019 ASH指南:镰状细胞病——心肺和肾脏疾病

2019年12月,美国血液病学会(ASH)发布了镰状细胞病指南——心肺和肾脏疾病的管理。终末期器官疾病的预防和管理是成人和儿童镰状细胞病(SCD)患者面临的主要调整,SCD患者心肺和肾脏疾病的筛查、诊断和管理的不确定性可可变性导致患者的不同结局。本文主要针对镰状细胞病患者心肺和肾脏并发症的筛查,诊断以及管理提出10条循证建议。对成人SCD以及静脉血栓栓塞患者的抗凝治疗时间也提出了建议。