JACC:年轻HFpEF患者更常见于肥胖男性,且猝死率高

2019-08-11 国际循环编辑部 国际循环

虽然,射血分数保留的心力衰竭(HFpEF)被认为是老年人的疾病,但年轻患者也可出现这种综合症。JACC发表的一项研究探讨了HFpEF患者的年龄、临床特征和预后的关系。

虽然,射血分数保留的心力衰竭(HFpEF)被认为是老年人的疾病,但年轻患者也可出现这种综合症。JACC发表的一项研究探讨了HFpEF患者的年龄、临床特征和预后的关系。
 


(图引自原文献)
 
使用3项大规模试验中左心室射血分数≥45%患者的数据(HFpEF试验、I-PRESERVE试验和CHARM试验),根据年龄对患者进行分类:≤55岁(n=522),56~64岁(n=1679),65~74岁(n=3405),75~84岁(n=2464),≥85岁(n=398)。研究比较不同年龄段的临床和超声心动图特征,死亡率和住院率,死亡方式和生活质量。
 
结果显示,患有HFpEF的年轻患者(年龄≤55岁)更多是肥胖,非白人男性,而年龄较大的HFpEF患者更多是白人女性,其心房颤动,高血压和慢性肾病患病率较高(eGFR<60 ml·min-1·1.73 m-2)。尽管合并症较少,但与年龄较大的患者(年龄≥85岁)相比,年轻患者的生活质量更差。与年龄≤55岁的患者相比,年龄≥85岁的患者死亡率更高(HR=6.9;95%CI:4.2~11.4)。然而,在死亡的患者中,猝死比例是年龄≤55岁的患者中最常见的死亡模式(P<0.001)。相比之下,年龄较大的患者(年龄≥85岁)更多地死于非心血管原因(34%vs. 20%;年龄≤55岁,P<0.001)。
 
研究提示,与老年人相比,年轻HFpEF患者是白人的可能性较小,更常见的是肥胖男性,并且更多地死于心血管原因,尤其是猝死。相比之下,老年HFpEF患者合并症更多,并且更常死于非心血管疾病。

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    2020-05-14 feather89
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    2019-10-29 hbwxf
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    2019-08-13 bettycmoon
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    2019-08-11 12196916m64(暂无昵称)

    涨知识了

    0

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