Diabetes Care:高血糖Covid-19患者结局分析

2020-05-27 MedSci原创 MedSci原创

胰岛素治疗可能是实现Covid-19患者血糖目标并改善预后的有效方法。

2型糖尿病患者任何感染的重要预后因素似乎都是血糖控制。没有关于高血糖患者严格控制血糖对Covid-19结局影响的信息。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员评估了最佳血糖控制对受Covid-19影响的高血糖患者的效果。

研究人员对59例中度疾病住院的Covid-19患者进行了评估。根据入院血糖>7.77mmol/L,将患者分为高血糖组和正常血糖组。在入院时和住院期间每周评估白介素6(IL-6)和D-二聚体水平。复合终点为严重疾病、入住重症监护病房、使用机械通气或死亡。

34例(57.6%)为正常血糖患者,25例(42.4%)为高血糖患者。在高血糖组中,入院前有18名(72%)患者已诊断出糖尿病,10名(40%)患者未注射胰岛素。无胰岛素输注组住院期间的平均血糖为10.65±0.84 mmol/L,胰岛素输注组为7.69±1.85mmol/L。基线时,高血糖组的IL-6和D-二聚体水平显著高于正常血糖组(P<0.001)。尽管所有患者均接受了Covid-19感染的标准治疗,但住院期间高血糖患者的IL-6和D-二聚体水平持续较高。在经过风险调整的Cox回归分析中,高血糖患者和糖尿病患者发生严重疾病的风险均比没有糖尿病和血糖正常的患者更高。Cox回归分析表明,与未注射胰岛素的患者相比,接受胰岛素治疗的高血糖患者发生严重疾病的风险较低。

由此可见,胰岛素治疗可能是实现Covid-19患者血糖目标并改善预后的有效方法。

原始出处:

Celestino Sardu,et al.Outcomes in Patients With Hyperglycemia Affected by Covid-19: Can We Do More on Glycemic Control?.Diabetes Care.2020.https://doi.org/10.2337/dc20-0723

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    2020-05-29 hbwxf
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