Lancet:中风早期给予硝酸甘油治疗不能改善患者预后

2019-03-12 zhangfan MedSci原创

研究认为,中风早期给予硝酸甘油治疗不能改善患者预后

高血压是急性脑卒中以及不良预后的重要因素,近日研究人员考察了在中风发病后早期服用硝酸甘油 (GTN)对改善预后的效果。

中风后4小时内的成年患者参与研究,其动脉血压120mmHg以上,随机接受GTN经皮制剂(每天5mg,持续4天)或安慰剂。研究的主要终点为90天Rankin评分(mRS)变化。

1149名患者参与研究,其中GTN组568人,对照组581人。发病到干预的平均时间为71min,缺血性中风患者597人,脑出血患者145人,短暂性缺血发作患者109人。GTN组患者平均动脉压较对照组低5.8mmHg,舒张压低2.6mmHg。研究发现,脑卒中或短暂性缺血性脑卒中人群接受GTN不会改善mRS评分(3 vs 3),对所有参与患者GTN的疗效也不显著(3 vs 3)。组间死亡率以及严重不良事件率差异不显著。

研究认为,中风早期给予硝酸甘油治疗不能改善患者预后。

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    2019-10-01 howi
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    2019-03-12 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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