Brit J Heamatol:老年人非贫血铁缺乏症的患病率和相关死亡率

2020-05-02 MedSci原创 MedSci原创

在英格兰的老年人中NAID很常见,并且相比于血清铁蛋白正常的非贫血个体,其死亡率增加。该相关性主要是由女性死亡率过高所致。

铁是多种生物学途径的核心物质,在某些疾病状态下,治疗非贫血性铁缺乏症(NAID)具有益处。但是,尚不清楚NAID是否与老年人死亡率增加有关。

近日,血液系统疾病权威杂志British Journal of Haematology上发表了一篇研究文章,研究人员使用了来自英国纵向老龄化研究的4451名老年人的全国代表性样本。NAID被定义为血清铁蛋白<30μg/l和血红蛋白≥120g/l(女性)或≥130g/l(男性)。研究人员通过Kaplan-Meier方法估算累积死亡率,并使用Cox比例风险回归模型计算未调整和调整后的死亡率风险比(HRs)。

基线NAID患病率为8.8%(95%置信区间[CI]为8.0-9.7%);女性为10.9%(95%CI为9.7-12.3%),男性为6.35%(95%CI为5.3-7.5%)。在14年的随访中,NAID患者与无铁缺乏的非贫血患者相比死亡的HR为1.58(95%CI为1.29-1.93)。这种关联独立于所有已知的人口统计学指标、与健康相关的生物学协变量,并且在多重敏感性分析中很可靠。

由此可见,在英格兰的老年人中NAID很常见,并且相比于血清铁蛋白正常的非贫血个体,其死亡率增加。该相关性主要是由女性死亡率过高所致。

原始出处:

Keir E. J. Philip.et al.The prevalence and associated mortality of non‐anaemic iron deficiency in older adults: a 14 years observational cohort study.british journal of haematology.2020.https://onlinelibrary.wiley.com/doi/10.1111/bjh.16409

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