IBD: 炎性肠病妇女产后疾病复发的发生率和预测因素

2020-11-29 MedSci原创 MedSci原创

患有炎症性肠病的产妇产后出现生理和心理压力可能会影响炎症性肠病的活动。在此期间疾病活动的预测因素和结果尚未很好地表征。因此,本项研究就此展开相关研究。

背景

患有炎症性肠病的产妇产后出现生理和心理压力可能会影响炎症性肠病的活动。在此期间疾病活动的预测因素和结果尚未很好地表征。因此,本项研究就此展开相关研究。

 

 

方法

研究人员对成功妊娠并活产的炎症性肠病患者进行了回顾性研究。从病历中提取了有关患者和疾病因素的数据,包括怀孕前后的疾病活动。研究人员注意到在怀孕期间的每个孕期和分娩后均应降低药物剂量或停止治疗。对产后出现复发的独立预测因子进行多变量logistic回归,并调整相关协变量。

 

 

结果

本项研究共确定了206名女性(平均年龄33.2岁)。其中,有97名(47%)被诊断为克罗恩氏病,其余的则患有溃疡性结肠炎。将近一半的妇女通过阴道分娩(53%),其余通过剖腹产分娩(47%)。在整个队列中,有65名(31.6%)在分娩后一年内经历了产后疾病复发。在多变量分析中,可通过妊娠中期的疾病活动预测产后发作的发生([OR],6.27; 95%置信区间[CI],2.81–17.27),妊娠期治疗的降级(OR,3.00; 95%CI,1.03–8.68),妊娠后治疗水平下降(OR,4.43; 95%CI,1.55–12.65)。产后疾病发作与疾病类型,疾病持续时间或分娩方式无关。

 

 

 

结论

三分之一的炎症性肠病妇女在产后一年内可能会出现疾病复发。怀孕之前,期间和之后,持续优化治疗方法对于预防这种疾病至关重要。

 

 

原始出处:

Amy Yu. Et al. Incidence and Predictors of Flares in the Postpartum Year Among Women With Inflammatory Bowel Disease. Inflammatory Bowel Diseases.2020.

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    2020-11-30 Sunny orchard

    心理压力和健康问题会通过身体问题表现出来

    0

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    2020-11-30 bnurmamat
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