Diabetes Care:代谢正常的小胖子,心血管疾病的风险也增加

2019-01-08 马传伟 山东大学

近日,山东大学席波教授团队在国际权威医学期刊《Diabetes Care》(IF=13.397)发表重要成果:代谢正常的小胖子,心血管疾病的风险也增加。

近日,山东大学席波教授团队在国际权威医学期刊《Diabetes Care》(IF=13.397)发表重要成果:代谢正常的小胖子,血管疾病的风险也增加。



近年来,某些学者认为 “健康肥胖”表型(即肥胖者的血压、血糖、血脂等生化指标均为正常)不会增加远期血管疾病和糖尿病的风险。但越来越多的证据表明,即使代谢正常的肥胖也会增加远期健康风险。既往研究主要关注成年群体,而较少关注儿童群体。该研究通过国际合作,联合了中国(n=1416),巴西(n=441)、希腊(n=439)、意大利(n=570)和西班牙(n=631)五国儿童研究数据,最终纳入共3497例儿童数据。研究通过BMI定义正常体重、超重和肥胖,根据血压偏高、血脂偏高和血糖偏高参数定义是否代谢健康,将颈动脉内膜中层厚度(cIMT)高于90百分位的定义为高cIMT(即血管结构异常)。结果表明,与代谢健康型正常体重者相比,代谢健康型超重和肥胖者的高cIMT风险分别增加129%和291%,代谢不健康型超重和肥胖者的高cIMT风险分别增加249%和596%。总之,对于“小胖子”来说,即使生化指标代谢正常,亚临床心血管疾病的风险也会增加,这提示减肥可能有助于改善心血管健康。该研究得到国家自然科学基金资助。

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    2019-01-08 明月清辉

    谢谢分享,学习了

    0

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