Hepatol Commun:猕猴桃中一种成分可预防非酒精性脂肪肝

2018-01-30 佚名 中国生物技术网

越来越多的证据表明,母亲在怀孕期间的饮食会对孩子产生显着的影响。如果她们在怀孕期间食用高脂肪饮食,那么“母债子偿”,孩子今后有可能是肥胖,也有可能是非酒精性脂肪肝。好在近日有一项新研究发现了防止非酒精性脂肪肝的方法。

越来越多的证据表明,母亲在怀孕期间的饮食会对孩子产生显着的影响。如果她们在怀孕期间食用高脂肪饮食,那么“母债子偿”,孩子今后有可能是肥胖,也有可能是非酒精性脂肪肝。好在近日有一项新研究发现了防止非酒精性脂肪肝的方法。

研究人员发现,猕猴桃、芹菜和木瓜中存在的一种名为吡咯喹啉醌(PQQ)的化合物,它能够预防母亲食用高脂肪饮食的小鼠患上非酒精性脂肪肝(NAFLD)。

这项研究由美国科罗拉多大学安舒茨医学院的麻醉学副教授Karen Jonscher博士主导,已于近日发表在《Hepatology Communications》上。

NAFLD被定义为肝脏中不是由酒精消耗引起的脂肪堆积,NAFLD是最常见的肝脏疾病。肥胖、高胆固醇高血压、高甘油三酯水平是NAFLD的主要诱因,这些疾病通常是由高脂肪饮食引起的。但我们需要关心的不仅仅是自己的饮食,我们的健康还会受到母亲在怀孕期间的饮食的影响。

孕妇饮食对后代的影响

近年来,大量的研究表明母亲的不良饮食会对发育中的胎儿产生负面影响。

比如,去年的一项研究表明,在怀孕期间摄入高脂肪饮食的母亲会使子女(甚至是孙辈)患乳腺癌的风险增高(DOI: 10.1186/s13058-017-0866-x)。

还有研究表明,在怀孕期间母亲饮食糟糕会改变后代的肠道菌群,使孩子更容易患肥胖和相关疾病(DOI: 10.1038/ncomms4889)。

Jonscher说:“越来越多的证据表明,母体肥胖会在子宫内造成炎症环境。这会导致产后长期破坏先天免疫系统和肠道细菌健康,还会增加发生脂肪肝疾病的风险。”

在过去的小鼠研究中,研究人员发现,给肥胖的怀孕小鼠补充PQQ可防止后代肝脏中的轻度脂肪堆积。

PQQ是以植物性食物为基础的化合物,包括猕猴桃、青椒、芹菜、香菜、木瓜,也存在于母乳中。PQQ是一种抗氧化剂。这意味着它能够保护身体不受自由基伤害。

在最近的这项研究中,Jonscher和同事们想确定母体补充PQQ是否有助于防止后代发生NAFLD。

NAFLD的“潜在的安全疗法”

为了实现研究目的,他们对怀孕小鼠喂食高脂肪的西式饮食,并监测其后代的健康状况。研究团队发现,这些小鼠后代的体重比母亲饮食受控的小鼠后代高出56%。

实验室组小鼠的肠道菌群也出现了变化,而这种变化与非酒精性脂肪性肝炎(NASH)相关,NASH是NAFLD的一种形式,在肝脏出现脂肪堆积的同时还伴随着炎症。

然而,当怀孕小鼠接受PQQ和高脂饮食时,研究人员发现它们后代NASH相关的肠道细菌变化被逆转,并且它们的体重增加也比没有接受PQQ的母亲所生的后代更少。Jonscher和同事们认为该结果表明PQQ可以作为预防NAFLD的一种可行方案。

研究人员在对这些结果的评论中写道:“尽管我们尚未对苗条和肥胖孕妇的人类和其他动物的进行研究,但是PQQ非常有潜力成为一种安全的治疗方法,它有助于预防NAFLD/NASH。”

Jonscher最后警告称,虽然PQQ可以作为一种补充剂,但是我并不建议人们现在就去买PQQ,在使用PQQ之前,还是应该先咨询医生。

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    2018-06-05 liuli5079
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    2018-02-01 gwc384
  6. [GetPortalCommentsPageByObjectIdResponse(id=1676385, encodeId=c68316e6385c2, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Tue Apr 17 12:20:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087268, encodeId=843a208e26891, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Tue Jun 05 05:20:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673369, encodeId=d09616e3369d7, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Tue Aug 07 21:20:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980472, encodeId=a9fc19804e260, content=<a href='/topic/show?id=099f9548ed7' target=_blank style='color:#2F92EE;'>#酒精性脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95487, encryptionId=099f9548ed7, topicName=酒精性脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Sun Aug 12 17:20:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426998, encodeId=81161426998dc, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Feb 01 05:20:00 CST 2018, time=2018-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283525, encodeId=28ab2835258a, content=食物水果防治疾病好., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Tue Jan 30 14:27:06 CST 2018, time=2018-01-30, status=1, ipAttribution=)]
    2018-01-30 1e0f8808m18(暂无匿称)

    食物水果防治疾病好.

    0

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