Circulation:先天性心脏病患者痴呆风险!

2018-02-14 xing.T MedSci原创

由此可见,与一般人群相比,CHD与老年痴呆症风险增加,尤其是早发性痴呆。进一步了解CHD患者痴呆风险是未来研究的一个潜在目标。

越来越多的先天性心脏病(CHD)儿童可以存活到成年,CHD与痴呆的危险因素有关。近日,心血管领域权威杂志Circulation上发表了一篇研究文章,研究人员比较了CHD成人与普通人群发生痴呆的风险。

在这项队列研究中,研究人员使用了涵盖所有丹麦医院的医疗登记中心和病例记录以确定在1963年至2012年期间诊断为CHD的成人。这些CHD患者从1981年1月1日、30岁或第一次CHD登记日随访至医院诊断痴呆、死亡、移民或研究结束(2012年12月31日)。对于每一个CHD患者,研究人员利用丹麦的民事登记系统匹配了性别和出生年份的10名普通人群。研究人员计算了痴呆的累积发生率和风险比(HRs),并根据性别和出生年份进行调整。

在10632名成人CHD患者中,80岁以上老年人痴呆累计发病率为4%(46%为男性)。CHD与一般人群相比,整体HR为1.6(95%可信区间[CI]为1.3-2.0)。没有心外缺陷的CHD患者HR为1.4(95%CI为1.1-1.8)。轻度至中度成年CHD患者的HR为1.5(95%CI为1.1-2.0),而包括单心室在内的严重CHD患者HR为2.0(95%CI为1.2-3.3)。早发性(<65岁)痴呆的HR为2.6(95%CI为1.8-3.8),而迟发性痴呆的HR为1.3(95%CI为1-1.8)。

由此可见,与一般人群相比,CHD与老年痴呆症风险增加,尤其是早发性痴呆。进一步了解CHD患者痴呆风险是未来研究的一个潜在目标。

原始出处:

Carina N. Bagge,et al. Risk of Dementia in Adults With Congenital Heart Disease: Population-Based Cohort Study.Circulation. 2018. https://doi.org/10.1161/CIRCULATIONAHA.117.029686

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    2018-02-16 huirong
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    2018-02-14 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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    2018-02-14 wqkm

    ^_^^_^^_^

    0

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