J Clin Periodontol:局部应用釉基质蛋白预防牙周再生术后的急性全身性炎症

2020-05-31 网络 网络

本实验旨在研究健康人使用釉基质蛋白(EMD)辅助手术治疗牙周骨吸收(IBD)的急相期反应。

本实验旨在研究健康人使用釉基质蛋白(EMD)辅助手术治疗牙周骨吸收(IBD)的急相期反应。

研究纳入38个牙周炎患者(每个患者有1个IDB),随机分为2组,有/无EMD辅助微创牙周手术。记录术前和术后6个月时的牙周参数。在术前,术后1天、7天和180天采集血液样本。

结果发现,术后24小时,EMD+MIS组的C-反应蛋白(CRP;p<.01)较低,没有炎症干扰。相反,MIS组在24小时(p<.05)时产生急性炎症反应,第7天回归到其基础值。术后6个月,EMD+MIS组没有BOP或PPD≥5mm的病例更多(p<.05),术后牙龈退缩较少(p<.05)。

EMD辅助手术治疗可以使术后24小时的血清CRP水平降低,改善急性炎症反应和临床牙周参数。因此,EMD可能具有全身性抗炎作用。

原文出处:

FilippoGraziani, Local application of enamel matrix derivative prevents acute systemic inflammation after periodontal regenerative surgery: A randomized controlled clinical trial,Journal of clinical periodontology, 2020 June,doi.org/10.1111/jcpe.13270

 

 

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    2021-02-28 feather89
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    2020-06-02 chg122
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