J Neurol Neurosurg Psychiatry: 脑小血管病是抗凝治疗患者发生脑出血的促成因素

2021-06-30 MedSci原创 MedSci原创

在服用抗凝药物的患者中,SVD是ICH的一个促成因素,并提示抗凝不再被视为ICH的充分“原因”。

脑小血管病(SVD)是非创伤性自发性脑出血(ICH)的绝大多数病因,在西欧的一项研究中,70岁或70岁以下的患者占77%,在西欧和美国的一项研究中,18岁或18岁以上的患者占77%–85%。随机对照试验的荟萃分析表明,口服抗凝剂维生素K拮抗剂和直接口服抗凝剂(阿哌沙班、达比加群、,依多沙班和利伐沙班)是脑出血的危险因素。然而,没有证据表明抗凝剂能导致动脉破裂、血管脆弱或抑制血管修复。在许多相互竞争的危险因素的背景下,抗凝剂对脑出血的直接独立作用尚不清楚。此外,大多数维生素K拮抗剂的ICH发生在治疗范围内。最近的一项研究发现,服用利伐沙班的ICH患者血浆水平较低。尽管有这些观察,口服抗凝治疗通常被认为是ICH的充分原因,并已用于ICH病因的临床和机制分类系统。或者,有人假设抗凝治疗可能加剧SVD引起的自发性“微出血”,导致症状性ICH。 Seiffge DJ,等探讨了小血管疾病(SVD)在抗凝血相关脑出血(ICH)中的作用研究结果发表在J Neurol Neurosurg Psychiatry杂志。 2型中风微出血的临床相关性包括两个独立的多中心观察研究:一是脑出血患者的横断面研究;其次

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    2021-07-25 yinhl1978
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