Lancet:阿奇霉素对缩短新冠肺炎疑似患者康复时间无显著效果

2021-03-08 MedSci原创 MedSci原创

疑似新冠肺炎患者的社区观察,对加速恢复和减少住院至关重要,特别是老年和患有共症的高风险患者。阿奇霉素是一种广泛使用的、廉价、安全药物,体外研究表明其具有抗SARS-CoV-2活性。统计发现,新冠肺炎疫

疑似新冠肺炎患者的社区观察,对加速恢复和减少住院至关重要,特别是老年和患有共症的高风险患者。阿奇霉素是一种广泛使用的、廉价、安全药物,体外研究表明其具有抗SARS-CoV-2活性。统计发现,新冠肺炎疫情期间,英国阿奇霉素社区使用率显著增加。
近日,研究人员考察了阿奇霉素对疑似Covid-19且伴有高并发症风险社区患者的疗效及安全性。
PRINCIPLE研究在英国开展,年龄在65岁以上或50岁以上且伴有至少1种共病的新冠肺炎疑似患者参与研究,患者病程不超过14天,在常规护理基础上,接受每日500mg的阿奇霉素或安慰剂,持续3天。研究的主要终点有2个,对于28天内自我报告疑似新冠肺炎症状恢复的患者,考察其恢复时间;未康复人群,考察其新冠肺炎相关住院或死亡。
 
2265名患者参与研究,其中540人接受阿奇霉素联合常规护理,875人仅接受常规护理,850人接受其他干预手段,94%的患者完成研究。500名完成研究的阿奇霉素组患者中,402人(80%)疑似新冠肺炎症状消失,823名仅接受常规护理的患者中,631人(77%)疑似新冠肺炎症状消失,没有证据表明,阿奇霉素对加速疑似患者康复有益(HR=1.08),组间康复时间的差异仅为0.94天,组间康复时间差异至少为1.5天的概率仅为0.23。阿奇霉素组16名患者住院,而常规护理组为28人(3% vs 3%)。研究期间,未发生患者死亡,组间非新冠肺炎相关住院率均为1%。
研究认为,对于在社区接受观察的疑似新冠肺炎患者,阿奇霉素治疗不能减少其康复时间
 
原始出处:
 
Butler et al. Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.Lancet. March 04, 2021.

 

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    2021-12-11 howi
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    2021-03-08 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2021-03-08 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1831055, encodeId=c088183105579, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Dec 11 01:18:02 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029219, encodeId=879c102921920, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Mar 08 22:18:02 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034201, encodeId=1c14103420188, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Mon Mar 08 22:18:02 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047299, encodeId=9f2f104e2999a, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Mar 08 22:18:02 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946568, encodeId=8e7994656855, content=赞同, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210308/ee92791efc274c3fa0b59c0ced8592b9/e0153faceb6943e38173dc65f2b4956e.jpg, createdBy=8ebe1507172, createdName=348511787, createdTime=Mon Mar 08 21:43:38 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946551, encodeId=5343946551b8, content=新冠肺在社区中管理很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210308/5d0cd08940d94f5687bbd0209d04633d/ec4b7a5333c046e9ab0574b2ab316002.jpg, createdBy=74205466959, createdName=ms4000000496520434, createdTime=Mon Mar 08 21:11:09 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946537, encodeId=994f94653ef5, content=非常有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=83372945156, createdName=984121077, createdTime=Mon Mar 08 20:29:21 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946530, encodeId=5e6e946530bb, content=研究非常前沿, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210308/6de5b09a0e2a4becae2a171296c0ef73/240c02dec7b84a2a8e7cebad2bd2f655.jpg, createdBy=dd4b5466938, createdName=unidoctor, createdTime=Mon Mar 08 20:20:44 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
    2021-03-08 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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    2021-03-08 348511787

    赞同

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1831055, encodeId=c088183105579, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Dec 11 01:18:02 CST 2021, time=2021-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1029219, encodeId=879c102921920, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Mon Mar 08 22:18:02 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034201, encodeId=1c14103420188, content=顶刊就是不一样,质量很高,内容精彩!学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=goodbing, createdTime=Mon Mar 08 22:18:02 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047299, encodeId=9f2f104e2999a, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Mar 08 22:18:02 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946568, encodeId=8e7994656855, content=赞同, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210308/ee92791efc274c3fa0b59c0ced8592b9/e0153faceb6943e38173dc65f2b4956e.jpg, createdBy=8ebe1507172, createdName=348511787, createdTime=Mon Mar 08 21:43:38 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946551, encodeId=5343946551b8, content=新冠肺在社区中管理很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210308/5d0cd08940d94f5687bbd0209d04633d/ec4b7a5333c046e9ab0574b2ab316002.jpg, createdBy=74205466959, createdName=ms4000000496520434, createdTime=Mon Mar 08 21:11:09 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946537, encodeId=994f94653ef5, content=非常有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=83372945156, createdName=984121077, createdTime=Mon Mar 08 20:29:21 CST 2021, time=2021-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946530, encodeId=5e6e946530bb, content=研究非常前沿, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210308/6de5b09a0e2a4becae2a171296c0ef73/240c02dec7b84a2a8e7cebad2bd2f655.jpg, createdBy=dd4b5466938, createdName=unidoctor, createdTime=Mon Mar 08 20:20:44 CST 2021, time=2021-03-08, status=1, ipAttribution=)]
    2021-03-08 ms4000000496520434

    新冠肺在社区中管理很重要

    0

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    2021-03-08 984121077

    非常有用

    0

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    2021-03-08 unidoctor

    研究非常前沿

    0

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