JAMA:新鲜胚胎移植vs胚胎冷冻解冻移植对新鲜供体卵母细胞体外受精辅助生殖活产率的影响

2021-01-18 MedSci原创 MedSci原创

对于接受新鲜供体卵母细胞体外受精辅助生殖的女性,新鲜胚胎移植的活产率高于胚胎冷冻解冻移植

研究证实,在自体卵细胞体外受精辅助生殖中,与新鲜胚胎移植相比,冷冻解冻胚胎移植后的活产率更高。而另一份统计数据发现,自1984年来,美国供体卵细胞体外受精辅助生殖率不断增加,到2016年以达到了9.2%,其胚胎移植后的活产率在40-50%之间。近日研究人员比较了新鲜胚胎移植 vs 冷冻解冻胚胎移植对供体卵细胞体外受精辅助生殖活产率的影响。
 
2014-17年间,33863名接受新鲜供体卵母细胞体外受精辅助生殖的女性参与研究,随机接受新鲜或冷冻解冻胚胎移植。研究的主要终点为活产率,次要终点为临床妊娠率和流产率。
 
组间参与者的平均年龄、怀孕次数以及体重指数相近,参与者总计接受了51942个供体卵细胞体外受精胚胎移植,其中15308例为新鲜胚胎移植,36634例为冷冻解冻胚胎移植(29.5% vs 70.5%),组间囊胚移植成功率相近(92.4% vs 96.5%),平均囊胚移植数量相近。新鲜胚胎移植组的活产率为56.6%,而冷冻解冻组为44.0%(RR=1.42)。新鲜胚胎移植组的临床妊娠率为66.7%,而冷冻解冻组为54.2%(RR=1.34)。新鲜胚胎移植组的流产率为9.3%,而冷冻解冻组为9.4%(RR=0.98)。
 
研究认为,对于接受新鲜供体卵母细胞体外受精辅助生殖的女性,新鲜胚胎移植的活产率高于胚胎冷冻解冻移植
 
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    2021-06-16 feather85
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    2021-01-20 ailian1202
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    2021-01-18 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1631889, encodeId=29de163188928, content=<a href='/topic/show?id=bd782682e3a' target=_blank style='color:#2F92EE;'>#供体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26827, encryptionId=bd782682e3a, topicName=供体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9ed21829086, createdName=feather85, createdTime=Wed Jun 16 11:55:58 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315479, encodeId=098513154e9e9, content=<a href='/topic/show?id=6fcc83e0554' target=_blank style='color:#2F92EE;'>#胚胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83705, encryptionId=6fcc83e0554, topicName=胚胎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6393434, createdName=ailian1202, createdTime=Wed Jan 20 05:55:58 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514581, encodeId=f45415145813d, content=<a href='/topic/show?id=690283e36cb' target=_blank style='color:#2F92EE;'>#胚胎移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83736, encryptionId=690283e36cb, topicName=胚胎移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a9910663000, createdName=ms2694732865965676, createdTime=Wed Jan 20 05:55:58 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539942, encodeId=e20a15399424d, content=<a href='/topic/show?id=98013806437' target=_blank style='color:#2F92EE;'>#受精#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38064, encryptionId=98013806437, topicName=受精)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=072113156483, createdName=旅苦化文_212, createdTime=Wed Jan 20 05:55:58 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625561, encodeId=c24d16255611b, content=<a href='/topic/show?id=95513689242' target=_blank style='color:#2F92EE;'>#卵母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36892, encryptionId=95513689242, topicName=卵母细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3b120824706, createdName=qingting, createdTime=Wed Jan 20 05:55:58 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036399, encodeId=16a9103639976, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon Jan 18 17:55:58 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=917755, encodeId=4ab191e7559c, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon Jan 18 15:19:47 CST 2021, time=2021-01-18, status=1, ipAttribution=)]
    2021-01-18 医鸣惊人

    认真学习了

    0