Cell Metabolism:益生菌可减缓急性和慢性肾脏疾病进展

2021-08-01 生物探索 生物探索

益生菌L.casei Zhang可减缓急性和慢性肾脏疾病的进展。

近年来,益生菌已被证明能促进微生物的生长,广泛存在于人体胃肠道中,在维持健康的微生态中发挥着重要作用,干酪乳杆菌张(L. casei Zhang)是一种从中国发酵酸奶样品中分离得到的益生菌,具有耐酸性、耐胆汁性以及在人类胃肠道定植的能力。口服干酪乳杆菌治疗能够调节免疫反应和肠道微生物群组成,并能特异性增强健康成人和老年人群的抗炎和抗氧化作用。

也有越来越多的证据表明,肠道微生物群失衡和肠粘膜屏障受损与炎症、氧化应激和各种肠道疾病的损伤有关,包括糖尿病肾病、狼疮性肾炎和IgA肾病。干酪乳杆菌L. casei Zhang已被证明通过调节肠道微生物群衍生代谢物的产生来减轻脂多糖诱导的急性肝损伤和胰岛素抵抗。然而,干酪乳杆菌尚未在人体试验或肾脏疾病的临床前研究中开展。

2021年7月15日,同济大学Rui Zeng等研究人员在《细胞—代谢》杂志上在线发表了题为“The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease”的文章,试验揭示益生菌L.casei Zhang可减缓急性和慢性肾脏疾病的进展。

首先,研究人员探讨了干酪乳杆菌对肾脏损伤的影响,在雄性小鼠遭受缺血/再灌注损伤前后给予口服/不口服干酪乳杆菌,实验表明,益生菌预处理后血清尿素氮(BUN)和肌酐值降低,肾脏的病理损伤较少,而在观察28天后,益生菌治疗的肾间质中的胶原沉积较低,特异性纤维化标志物a-SMA和I型胶原的表达显着降低,观察期延长至45天,肾间质纤维化有所改善。这都表明早期或晚期预防性使用益生菌干酪乳杆菌与较低的急性肾损伤和慢性肾纤维化相关。此外,在对小鼠肠道微生物进行测序分析显示,用干酪乳杆菌预处理后显示出改善缺血/再灌注引起的生物失调、肠道炎症和肠粘膜屏障损伤的优越能力。

小鼠粪便样本的测序分析

随后,研究人员探讨了肠道菌群在肾损伤中的作用以及益生菌治疗的效果是否依赖于原始肠道菌群,实验表明,在用广谱抗生素(ABX)耗尽原始肠道菌群后,干酪乳杆菌仍有保护肾功能的作用,干酪乳杆菌的保护作用并不完全依赖于原始肠道菌群的存在。在进一步的进行机制研究发现,干酪乳杆菌的保护作用依赖于免疫调节性巨噬细胞和肾小管上皮细胞。

干酪乳杆菌的保护作用与其抑制免疫调节性巨噬细胞和肾小管上皮细胞的炎症反应有关

最后,研究人员还进行了一项为期1年的口服L. casei Zhang的安慰剂对照研究(中国临床试验注册中心,ChiCTR-INR-17013952),纳入了62例3-5期慢性肾病患者,随机分组到安慰剂或干酪乳酸菌组,观察了3个月和1年后两组患者的肾功能指标,试验表明干酪乳酸菌组的耐受性良好,减缓了3-5期CKD患者的肾脏功能下降。

实验机制图

总之,本篇文献揭示了肠道菌群失调在肾脏疾病的进展中起着重要作用。口服干酪乳杆菌通过肠道微生物来源的代谢物调节肾小管上皮细胞和巨噬细胞的炎症反应,减缓急性和慢性肾病的进展。这些结果为AKI和CKD的治疗提供了新的治疗靶点。

原始出处:

Han Zhu, et al. The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease. Cell Metabolism, 2021.

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    2022-07-12 guojianrong
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    2022-05-02 一闲
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    2021-10-07 维他命
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    2021-08-21 铛铛2673

    是华中科技大学,不是同济大学

    0

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    2021-08-08 12192b1am98暂无昵称

    学习了

    0

  8. 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    2021-08-02 仁心济世
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