Gastroenterology:乳糜泻与小肠腺癌风险研究

2020-11-29 网络 网络

乳糜泻人群的小肠腺癌绝对风险不高,但与健康人群相比,乳糜泻人群小肠腺癌,腺瘤而非类癌风险增加

近年来小肠癌的发病率增加增加。 小规模研究发现,乳糜泻(CD)与小肠癌风险相关,但这一结论尚未得到大规模研究的证实。
 
本次研究在瑞典开展,为全国流行病学研究,从瑞典28个病理机构检索了1965年至2017年所有CD诊断的患者数据。CD患者的定义为十二指肠或空肠绒毛萎缩(Marsh得分III级),与来自一般人群的多达5个随机个体相匹配,使用分层COX回归计算小肠腺癌、腺瘤和类癌的危险比。
 
平均随访11年,总计定义了48119例CD患者和239249名匹配对照志愿者。在CD确诊后1年,29名患者(0.06%)确诊为小肠腺癌,而对照队列中,45名患者确诊(0.02%);7名CD患者确诊为类癌,对照组31人;48名CD患者确诊为腺瘤,而对照组50人,相应的小肠腺癌、类癌以及腺瘤风险分别为3.05、0.59和5.73。年龄及性别对风险无显著影响。在10年中,每2944名CD患者中,有1例额外的小肠腺癌确诊病例。黏膜愈合可降低后续小肠腺癌风险(0.18),但未达到统计学的显著意义。
 
来自瑞典的研究证实,乳糜泻人群的小肠腺癌绝对风险不高,但与健康人群相比,乳糜泻人群小肠腺癌,腺瘤而非类癌风险增加。
 
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    2021-08-22 许安
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    2021-07-30 小小医者

    #乳糜泻#与小肠癌?本来小肠癌就是极少的吧

    0

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  8. 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  9. 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    2020-11-29 爱读书的大丽子

    腺癌,腺瘤,和类癌的区别是?

    0

  10. 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createdBy=dafe5224615, createdName=爱读书的大丽子, createdTime=Sun Nov 29 23:26:36 CST 2020, time=2020-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=903371, encodeId=41599033e110, content=相关性学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60182229007, createdName=1211c54em14(暂无昵称), createdTime=Sun Nov 29 21:08:15 CST 2020, time=2020-11-29, status=1, ipAttribution=)]
    2020-11-29 1211c54em14(暂无昵称)

    相关性学习了

    0

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NCCN临床实践指南:小肠腺癌(2020.V1)

2019年7月,美国国家综合癌症网络(NCCN)发布了小肠腺癌指南2020年第1版,文章总结了NCCN对小肠腺癌的管理指导,内容涉及小肠腺癌的临床表现,诊断,病例分歧,手术治疗,围术期管理,患者监测以及疾病复发的管理等。

ANN ONCOL:蛋白结合型紫杉醇治疗复发性小肠腺癌和高CIMP结直肠癌

CPG岛启动子超甲基化(CIMP)是一种结直肠癌发生的特殊路径,其特征为缺少染色体不稳定性和腺瘤性息肉(APC)突变率低,这些均与紫杉烷耐药有关。与之相似的,小肠腺癌(SBA),一种罕见的肿瘤,APC突变率也很低。ANN ONCOL近期发表了一篇文章,评估紫杉烷在SBA和CIMP-high结直肠癌中的敏感性

应用减瘤手术和化学疗法成功治疗小肠腺癌的复发

引言: 小肠原发恶性肿瘤仅占全胃肠道恶性肿瘤的2.4%[1]。腺癌是小肠最常见的恶性肿瘤,约占小肠全部恶性肿瘤的1/3[2]。小肠腺癌(SBA)最常见的累及部位是十二指肠(52%-55%),其次是空肠(18%-25%)和回肠(13%),其它类型占10%-14%[2,3]。症状的非特异性和有效诊断方法的缺乏导致了小肠腺癌(SBA)的诊断常常被延误。据报道,被诊断为I期,II期,III期和I