Dig Dis Sci:乳糜泻患者患急性和慢性胰腺炎的风险明显增高

2021-07-30 MedSci原创 MedSci原创

乳糜泻 (CD) 是一种慢性免疫介导的肠病,由遗传易感个体接受膳食中的麸质食物诱发的。一些研究报告说,CD 人群中胰腺炎的发病率较高。

      乳糜泻 (CD) 是一种慢性免疫介导的肠病,由遗传易感个体接受膳食中的麸质食物诱发的。一些研究报告说,CD 人群中胰腺炎的发病率较高。为此,本项研究试图通过收集美国国家医疗数据库进行CD 患者急性胰腺炎 (AP) 和慢性胰腺炎 (CP) 的流行病学、风险和结果的分析。

 

      通过对卫生系统数据分析和研究平台(美国俄亥俄州克利夫兰医疗中心)的分析后,研究人员筛选了一组诊断为 CD 的患者进入本项研究。随后,进行多元回归模型以调整多个混杂因素分析那些被诊断为 CD 后至少 30 天后又被新诊断为 AP 和 CP 的个体,最后进行了统计学比较。

 

 

      在数据库中总共筛选了72965940 名患者,所有患者分别有 133400 (0.18%)、362050 (0.50%) 和 95,190 (0.13%)名患有 CD、AP 和 CP。CD 诊断至少 30 天后新诊断的 AP 和 CP 分别为 1.06% 和 0.52%,而非 CD 患者的 AP 和 CP 分别为0.49%和 0.13%,P < .0001。在多元回归分析中,CD 患者发生 AP 的风险较高 [OR 2.66; 95%CI 2.55–2.77] ,CP的危险也明显增加 [OR 2.18; 95%CI 2.04–2.34]。同时研究人员还发现特发性 AP 是 CD 患者中最常见的病因 [OR 1.54;95%CI 1.34–1.77]。

 

      本项研究证实在CD 患者中发生 AP 和 CP 的风险明显增加。与非 CD 患者相比,乳糜泻患者的预后更差,医疗负担更高。因此根据胰腺炎的病因、特发性胰腺炎的症状或胰酶升高的复发性腹痛应检查患者是否患有CD。

 

 

 

原始出处:

Motasem Alkhayyat. Et al. The Risk of Acute and Chronic Pancreatitis in Celiac Disease. Digestive Diseases and Sciences.2021.

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    2021-12-17 14775a26m11暂无昵称

    学习了

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    2021-08-01 liuxiaona
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    2021-07-30 小小医者

    #乳糜泻#患者患急性和慢性#胰腺炎#风险增加

    0

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