JCC: 炎症性肠病女性剖腹产后的产后手术并发症发生率增加

2021-11-03 MedSci原创 MedSci原创

溃疡性结肠炎和克罗恩病通常会影响女性的生育。但近年来,炎性肠病(IBD)研究领域的进展使许多女性患者成功妊娠,这使得生育这个家庭计划得到消化科医师和患者的共同关注。

炎症性肠病 (IBD) 通常会在患者育龄期间被诊断出来,通常与怀孕时间重合。IBD女性患者比一般人群的剖腹产率高,但其原因尚不清楚。女性剖腹产的风险包括感染、产后出血、麻醉反应、血栓、伤口感染、手术损伤等。这些风险在患有IBD的女性中可能会明显增加,尤其是那些使用免疫抑制剂或处于疾病活动期。本项研究的目标是确定接受剖腹产而不是阴道分娩的炎症性肠病 (IBD) 女性的产后 30 天手术并发症发生率之间的差异。

 

研究人员收集了1997年1月1日至2015年12月的生育的妇女资料,将所有剖腹产或阴道分娩的 IBD 母亲纳入本项研究中。然后比较了产后 30天产妇腹部和会阴部的手术结果,并针对多个混杂因素进行了调整。研究人员对急诊与选择性剖腹产以及免疫抑制疗法对产后并发症的影响。

 

研究结果显示在患有IBD的女性中,有2.1%的剖腹产妇女 (n=3,255) 和 0.3% 的阴道分娩妇女 (n=6,425) 有手术并发症。剖腹产的 IBD 女性更有可能进行小肠和结肠手术((aOR) 5.00,95% CI 2.00-12.51)。无论是急性 (aOR 4.51, 95% CI 1.48-13.76) 还是择期 (aOR 6.52, 95% CI 2.45-17.33) 剖腹产,都发现了类似的结果。研究人员还发现无论是否使用免疫抑制剂(使用免疫抑制剂的 aOR:8.79,95% CI 2.86-27.05)和(未使用免疫抑制剂的 aOR:4.49,95% CI 1.74-11.58),剖腹产术后的手术风险都会增加。

 

本项研究证实与阴道分娩相比,无论剖腹产是出于急诊还是选择性的原因或者在分娩前使用免疫抑制剂,IBD女性剖腹产术后发生手术并发症的风险增加。因此许多消化科医师认为,对于无复杂疾病的克罗恩病妊娠妇女,在决定其分娩方式时,更应该   慎重。

原始出处:

Sonia Friedman. et al. Postpartum surgical complications in women with inflammatory bowel disease after caesarian section: A Danish nationwide cohort study. Journal of Crohn's and Colitis.2021.

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    2022-08-27 丁鹏鹏
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抗肿瘤坏死因子α(抗TNFα)药物被广泛用作炎症性肠病(IBD)患者的维持治疗。成功诱导缓解后,但是仍然有高达13%-21%的患者会对抗TNFα失去治疗反应。

J Gastroenterology:黏膜 IL23A 表达水平可预测炎症性肠病对乌司奴单抗的反应

炎症性肠病 (IBD) 包括溃疡性结肠炎 (UC) 和克罗恩病 (CD),是一种难治性的胃肠道的慢性炎症。