Hypertension:怀孕时高果糖摄入可诱导多代子孙发生心脏代谢综合征

2019-08-20 MedSci MedSci原创

虽然母体高果糖摄入可诱发成年子女发生心脏代谢综合征,但它是否会诱发连续几代人发生高血压尚未有相关研究。Ho Yeong Seong等人推测母亲高果糖摄入可诱发多代子孙的肾素-血管紧张素-醛固酮系统激活。给妊娠小鼠的饮用水中加入20%的果糖,其第一代到第四代后代在没有果糖的情况下喂养长大。监测各代小鼠的血压,检测其mRNA表达水平,同时评价纤维化程度。与对照组相比,母体高果糖摄入显著增加了第一代和第

虽然母体高果糖摄入可诱发成年子女发生心脏代谢综合征,但它是否会诱发连续几代人发生高血压尚未有相关研究。Ho Yeong Seong等人推测母亲高果糖摄入可诱发多代子孙的肾素-血管紧张素-醛固酮系统激活。

给妊娠小鼠的饮用水中加入20%的果糖,其第一代到第四代后代在没有果糖的情况下喂养长大。监测各代小鼠的血压,检测其mRNA表达水平,同时评价纤维化程度。

与对照组相比,母体高果糖摄入显著增加了第一代和第二代子代的血压,但第三代和第四代子代的血压没有显著增加,但第三代子代的血清肾素、血管紧张素II和醛固酮的升高幅度最大。

此外,第一代至第三代子代小鼠的肾素血管紧张素醛固酮系统基因的mRNA表达水平以及肾脏的肾素表达均增加,除了血管舒张的Mas1基因,Mas1基因在第二代子代中的表达最低。

研究人员还发现母体高果糖摄入大大增加了第二代小鼠的炎性细胞因子的mRNA表达和肾纤维化,而且第一代至第三代小鼠的氧化因子的mRNA表达水平增加,但抗氧化编码基因Sod1的mRNA表达水平降低最多的是在第二代小鼠。

综上所述,母体高果糖摄入可诱导多代 子孙的肾素-血管紧张素-醛固酮系统激活,提示表观遗传可诱导多代子代发生心脏代谢综合征

原始出处:

Ho Yeong Seong, et al.

Hypertension. 22 Jul 2019;74:518–525. https://doi.org/10.1161/HYPERTENSIONAHA.119.12941

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