Am J Clin Nutr:诺如病毒感染后机体微量元素和炎症血清生物标志物浓度的变化

2020-10-02 MedSci原创 MedSci原创

本研究旨在评估微量营养素状态,有必要确定炎症和急性期反应对营养素生物标志物的影响,研究结果已在线发表于Am J Clin Nutr。

本研究旨在评估微量营养素状态,有必要确定炎症和急性期反应对营养素生物标志物的影响,研究结果已在线发表于Am J Clin Nutr。

在诺如病毒人类挑战研究中,研究人员旨在通过感染状态模拟C反应蛋白(CRP)和α-1-酸糖蛋白(AGP)的炎症反应,通过炎症状态模拟微量营养素生物标志物的动力学,并评估诺如病毒暴露后0~35 d炎症和微量营养素生物标志物之间的关联。

 

研究纳入了52名健康成年人,并长期跟踪;所有的人都暴露于诺如病毒,一半被感染。对炎症和营养生物标志物进行了事后分析。受试者按诺如病毒暴露导致的炎症进行分层。平滑回归模型按感染状态分析CRP和AGP的动力学,按炎症分析营养生物标志物。使用线性混合效应模型分析CRP、AGP和铁、维生素A、维生素D、维生素B-12、叶酸等生物标志物从诺如病毒暴露后0~35 d之间的独立关系。

 

结果显示,诺如病毒感染的受试者的CRP[16.0(7.9-29.5)mg/L]和AGP[0.9(0.8-1.2)g/L]的中位数(IQR)峰值浓度分别出现在暴露后第3天和第4天。炎症组内与基线不同的营养生物标志物(P<0.05)是铁蛋白(第3天升高)、肝素(第2、3天升高)、血清铁(第2-4天降低)、转铁蛋白饱和度(第2-4天降低)和视黄醇(第3、4、7天降低)。营养生物标志物浓度在未发病组内不随时间变化而变化。在混合模型中,CRP与铁蛋白(阳性)和血清铁和视黄醇(阴性,P<0.05)相关。

总之,该研究结果表明,在健康成人中使用实验性感染性挑战模型,诺如病毒感染引起了与某些铁和维生素A生物标志物的血清浓度改变相关的时间限制性炎症反应,证实了在评估营养状况时需要考虑调整这些生物标志物以解决炎症。

 

原始出处:

 

Anne M WilliamsChandresh N Ladva, et al., Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge. Am J Clin Nutr. 2019 Dec 1;110(6):1456-1464. doi: 10.1093/ajcn/nqz201.

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