J INTERN MED:SARS-CoV-2阳性和阴性个体1年时症状和功能障碍

2022-03-22 MedSci原创 MedSci原创

SARS-CoV-2感染会导致持续数月的症状,包括年轻的健康个体,除了大流行的影响外,而且可能比其他常见的呼吸道感染更严重。

严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)的持续症状在感染后数周至数月内普遍存在。迄今为止,很难将SARS-CoV-2的直接影响与间接影响区分开来,包括社区封锁、社会和经济因素造成的间接影响。

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,该研究旨在描述SARS-CoV-2检测呈阳性的门诊个体与检测呈阴性的个体在12个月时的症状患病率、功能能力和生活质量

从2021年4月23日至7月27日,研究人员纳入了在日内瓦大学医院接受SARS-CoV-2检测的有症状的门诊个体,并在检测日期后12个月内进行了随访。

在随访结束12个月时,在1447名参与者中(平均年龄为45.2岁,61.2%为女性),研究人员发现33.4%的患者报告SARS-CoV-2感染后伴有残存的轻度至中度症状,而对照组为6.5%。症状包括疲劳(16% vs. 3.1%);呼吸困难(8.9% vs. 1.1%);头痛(9.8% vs. 1.7%);失眠(8.9% vs. 2.7%)和注意力不集中(7.4% vs. 2.5%)。与对照组相比,30.5%的SARS-CoV-2阳性个体在12个月时报告功能受损,而对照组这一比例为6.6%。总体而言,SARS-CoV-2感染与症状持续存在(调整后的比值比aOR为4.1;2.60-6.83)和功能障碍(aOR为3.54;2.16-5.80)有关,在女性、男性、40岁以下、40-59岁以及既往没有病史或精神病史的个体亚组中也是如此。

由此可见,SARS-CoV-2感染会导致持续数月的症状,包括年轻的健康个体,除了大流行的影响外,而且可能比其他常见的呼吸道感染更严重。症状会影响患者感染后长达12个月的功能状态。

原始出处:

Mayssam Nehme,et al.1-year persistent symptoms and functional impairment in SARS-CoV-2 positive and negative individuals.Journal of Internal Medicine.2022.https://onlinelibrary.wiley.com/doi/10.1111/joim.13482

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    2023-02-21 hukaixun
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    2022-03-23 小刀医生
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    2022-03-22 杨海东

    坚持学习

    0

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    2022-03-22 mswert122

    图不见了

    0

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最近,有研究人员调查了含有瑞士乳杆菌SBT2171(LH2171)的发酵乳(FM)对轻度和中度常年过敏个体主观症状的影响。

声音嘶哑检查竟是喉癌,医生提醒:出现这些症状要小心

据统计,喉癌在头颈肿瘤中常见程度位居第二,喉癌发病率占全身恶性肿瘤约1-5%。因为喉部是人体的吞咽、发音和呼吸器官,因此喉部疾病往往会导致发音障碍和呼吸困难。

Mol Med Rep:miR-31能够抑制白细胞介素-13诱导的鼻腔上皮炎症反应来减轻过敏性鼻炎症状

最近,有研究人员调查了是否microRNA(miR)-31在过敏性鼻炎(AR)中能够发挥治疗潜力,并探索了其潜在的机制。

英国专家将新冠疾病分成6组症状群,或有助针对性治疗

据欧联网援引欧联社综合报道,近日,英国科学家将新冠病毒疾病分为了6种不同的“类型”,这可能有助于新冠病毒感染的治疗。研究人员表示,这可以帮助医生更好地针对具体病人进行酌情治疗,