J Hypertens:低密度脂蛋白胆固醇血症、血尿酸水平与高血压的相互作用

2018-10-13 xing.T MedSci原创

由此可见,在整体健康的人群样本中,LDL-C和SUA水平不正常与发生高血压的风险增加有关。

以前的证据表明较高水平的低密度脂蛋白胆固醇(LDL-C)和血清尿酸(SUA)是内皮功能障碍和血管衰老的危险因素。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员的研究目的是评估整体健康个体样本中SUA、LDL-C与高血压事件之间的短期相互作用。

在2018年1月,研究人员从布里西盖拉心脏研究的一般数据库中选择了四组年龄和性别匹配的非高血压个体,这些个体具有不同的LDL-C和SUA水平,并在2008年的人口调查中进行了检查。高血压的定义为SBP值超过140 mmHg和/或DBP超过90 mmHg,和/或开始抗高血压治疗。

在调整年龄、性别、基线血压、高血压家族史、吸烟状况、BMI和体力活动强度的模型中,与基线正常LDL-C和SUA水平的个体相比,高血压发生发展的风险比对于单独LDL-C升高的个体为1.14 [95%CI为0.87-1.55],对于单独SUA水平升高的个体的1.55(95%CI为0.96-2.48),对于LDL-C和SUA水平均升高的个体为1.57(95%CI为1.20-2.15)。

由此可见,在整体健康的人群样本中,LDL-C和SUA水平不正常与发生高血压的风险增加有关。

原始出处:

Cicero, Arrigo F.G.et al. Interaction between low-density lipoprotein-cholesterolaemia, serum uric level and incident hypertension: data from the Brisighella Heart Study. Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Interaction_between_low_density.97322.aspx

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    2019-04-17 feather89
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content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sun Oct 14 11:24:57 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2018-10-16 医者仁心5538

    学习了

    0

  5. 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content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sun Oct 14 11:24:57 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2018-10-16 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  6. 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  7. 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  8. 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content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sun Oct 14 11:24:57 CST 2018, time=2018-10-14, status=1, ipAttribution=)]
    2018-10-15 quxin068
  9. 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    2018-10-15 ylz8405
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    2018-10-14 一个字-牛

    学习了谢谢分享

    0

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