Comput Math Methods Med:牙周治疗可有效降低慢性牙周炎患者促炎性细胞因子的水平

2022-08-16 MedSci原创 MedSci原创

牙周炎作为一种常见的侵犯牙龈和牙周组织的慢性炎症,也是一种以进行性附着丧失和牙槽骨丧失为特征的慢性感染性疾病。在慢性牙周炎(CP)的发展过程中,患者血清和龈沟液(GCF)中炎症因子的水平会发生变化。

牙周炎作为一种常见的侵犯牙龈和牙周组织的慢性炎症,也是一种以进行性附着丧失和牙槽骨丧失为特征的慢性感染性疾病。在慢性牙周炎(CP)的发展过程中,患者血清和龈沟液(GCF)中炎症因子的水平会发生变化。近日,发表于Comput Math Methods Med的一项荟萃分析系统地评估了牙周治疗对CP患者GCF和血清中促炎症细胞因子(IL-6、TNF-α和IL-8)水平的影响。

研究人员系统检索了PubMed、Web of Science、Embase、中国国家知识基础设施(CNKI)和万方数据库中收录的2015年至2020年间比较牙周治疗(实验组)和对照组的细胞因子水平的随机对照试验。此外,还对相关文章、会议论文和摘要的参考文献列表进行了额外的检索,以挖掘出其他潜在的文章。

结果,共纳入13项研究,包括1220名患者,其中实验组有630例,对照组有590例。荟萃分析结果显示,与治疗前相比,实验组的GCF(SMD=-2.88,95%CI(-3.68,-2.09),P<0.001)和血清(SMD=-1.27,95%CI(-1.72,-0.81),P<0.001)中的IL-6水平明显降低。此外,实验组的GCF(SMD = -2.08,95% CI(-3.40,-0.76),P < 0.001)和血清(SMD = -1.73,95% CI(-2.76,-0.70),P < 0。 001)中的IL-8水平在牙周治疗后减少,但更多的是观察到治疗后GCF(SMD = -3.98,95% CI(-5.23,-2.73),P < 0.001)和血清(SMD = -1.80,95% CI(-3.16,-0.45),P < 0.001)的TNF-α水平的下降。

综上所述,该研究结果表明,牙周治疗后,CP患者GCF和血清中的促炎症细胞因子与治疗前相比明显下降,疗效显著,因此值得临床推广牙周治疗。

原始出处:

Jiahui Ren, Hong Li. Effects of Periodontal Treatment on Levels of Proinflammatory Cytokines in Patients with Chronic Periodontitis: A Meta-Analysis. Comput Math Methods Med. 2022 Jul 26;2022:9349598. doi: 10.1155/2022/9349598.  

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    2022-12-04 一闲
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