超50万国人11年前瞻研究:喝奶致癌是真的?!其中每天多喝50g,这3种癌风险就多上升超10%!

2022-05-09 LILYMED MedSci原创

BMC Med:中国成年人的乳制品消费量以及总癌症和特定部位癌症的风险:一项针对50万人的11年前瞻性研究。

以前对主要西方人群的研究报告了乳制品消费与某些癌症的对比关联,包括与前列腺癌的正相关以及与结直肠癌和绝经前乳腺癌的负相关。然而,来自中国的数据有限,癌症发病率和乳制品消费水平与西方人群有很大不同。

2004-2008年,中国慢性病前瞻性研究(CKB研究)从中国十个不同地区(五个城市,五个农村地区)纳入了约50万成年人。在基线和随后的重新调查中,使用经过验证的访谈者管理通过问卷形式向参与者收集包括乳制品在内的主要食物种类的食用频率信息,为了量化乳制品摄入量与癌症风险的线性关联并考虑回归稀释偏倚,通过结合基线和第二次重新调查的消费水平来估计每个基线组的平均通常消费量。在平均随访10.8年(SD 2.0)年中,在基线时没有癌症的510146名参与者中记录了29277例癌症病例。对与通常乳制品摄入量相关的癌症事件进行Cox回归分析,按风险年龄,性别和地区进行分层,并根据癌症家族史,教育,收入,酒精摄入量,吸烟,身体活动,大豆和新鲜水果摄入量以及体重指数进行调整。

总体而言,在本项研究所包含的51万余人中,20.4%的人经常食用乳制品(主要是牛奶)(即≥1天/周),68.5%从不或很少食用乳制品,人群平均乳制品的消耗量为每天37.9克,而经常食用者的平均消耗量为每天80.8克。经常食用乳制品者的癌症总体发病风险提高9% (HR =1.09 ,95% CI 1.06–1.12)、肝癌发病风险提高18% (1.18; 1.08–1.29)以及女性乳腺癌风险提高22% % (1.22; 1.12–1.32)。乳制品消费与总癌症和某些部位特异性癌症的风险存在显着的正相关,调整后的每多摄入乳制品50 g /天,对于总癌症、肝癌(n = 3191)女性乳腺癌(n = 2582)和淋巴瘤(n = 915)的HR分别为1.07(95%CI 1.04-1.10),1.12(1.02-1.22),1.19(1.01-1.41)和1.17(1.07-1.29)。

然而,在多重检验校正后,与淋巴瘤的相关性没有统计学意义。与结直肠癌(n = 3350,1.08 [1.00-1.17])或其他特定部位的癌症没有观察到显著的关联。

总之,在乳制品消费量相对低于西方人群的中国成年人中,乳制品摄入量越高,患肝癌、淋巴瘤和女性乳腺癌的风险越高。本研究是中国第一个也是最大的前瞻性队列研究,该研究显示在中国乳制品消费水平低但不断增加的地区,乳制品摄入量与总癌症和几种特定位点癌症风险之间存在正相关。未来的研究需要建立因果关系和潜在机制。本研究的发现结合未来的研究可能为中国癌症预防的循证饮食建议提供重要信息。

 

原文来源:

Kakkoura MG, Du H, Guo Y, Yu C, Yang L, Pei P, Chen Y, Sansome S, Chan WC, Yang X, Fan L, Lv J, Chen J, Li L, Key TJ, Chen Z; China Kadoorie Biobank (CKB) Collaborative Group. Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people. BMC Med. 2022 May 6;20(1):134. doi: 10.1186/s12916-022-02330-3. PMID: 35513801.

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    2022-10-13 sjq027
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    2022-05-09 ms1000000706626196

    谢谢分享

    0

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    2022-05-10 1064510_1039
  4. [GetPortalCommentsPageByObjectIdResponse(id=2062090, encodeId=a18020620909e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Thu Oct 13 12:29:03 CST 2022, time=2022-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218297, encodeId=29fa121829e92, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dba78146883, createdName=ms1000000706626196, createdTime=Mon May 09 22:46:39 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218345, encodeId=49e6121834503, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Tue May 10 08:06:36 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218340, encodeId=bd021218340fc, content=学习了<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/gKNgZiaia7XBE8lJLn1fp5u443yIhUNiaN9RztibctRREAGYVEtL7eC22wG0DzYdDiaiaTAEg4HaotaF4icegqk4VQvCA/132, createdBy=d6182579909, createdName=西瓜0628, createdTime=Tue May 10 07:39:39 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218333, encodeId=81b4121833312, content=不错学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=ms5000000644045955, createdTime=Tue May 10 06:55:35 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218326, encodeId=5e1212183267e, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71a21323878, createdName=348713009, createdTime=Tue May 10 00:55:49 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218286, encodeId=8b5b12182860f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 09 21:38:06 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218266, encodeId=9615121826682, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon May 09 20:15:25 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371056, encodeId=744313e1056e1, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Mon May 09 01:29:03 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-05-10 西瓜0628

    学习了#学习#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2062090, encodeId=a18020620909e, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Thu Oct 13 12:29:03 CST 2022, time=2022-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218297, encodeId=29fa121829e92, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dba78146883, createdName=ms1000000706626196, createdTime=Mon May 09 22:46:39 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218345, encodeId=49e6121834503, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Tue May 10 08:06:36 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218340, encodeId=bd021218340fc, content=学习了<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/gKNgZiaia7XBE8lJLn1fp5u443yIhUNiaN9RztibctRREAGYVEtL7eC22wG0DzYdDiaiaTAEg4HaotaF4icegqk4VQvCA/132, createdBy=d6182579909, createdName=西瓜0628, createdTime=Tue May 10 07:39:39 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218333, encodeId=81b4121833312, content=不错学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=ms5000000644045955, createdTime=Tue May 10 06:55:35 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218326, encodeId=5e1212183267e, content=学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71a21323878, createdName=348713009, createdTime=Tue May 10 00:55:49 CST 2022, time=2022-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218286, encodeId=8b5b12182860f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 09 21:38:06 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218266, encodeId=9615121826682, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Mon May 09 20:15:25 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1371056, encodeId=744313e1056e1, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Mon May 09 01:29:03 CST 2022, time=2022-05-09, status=1, ipAttribution=)]
    2022-05-10 ms5000000644045955

    不错学习了。

    0

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    2022-05-10 348713009

    学习了!

    0

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    2022-05-09 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2022-05-09 医鸣惊人

    认真学习了

    0

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    2022-05-09 jambiya

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