Nature:治疗秃顶有望!研究人员完全由多能干细胞产生的人体皮肤毛发  

2020-06-04 MedSci原创 MedSci原创

在4-5个月的培育期内,研究人员观察到由分层表皮、富含脂肪的真皮层和带有皮脂腺的色素性毛囊组成的皮肤类器官的出现。

皮肤是一个多层次的器官,配备有附属物(即毛囊和腺体),是调节体温和体液的保留,抵御外部压力,和调解触摸和疼痛的感觉的关键。在文化和生物工程移植物中,重建附属器官的皮肤是一个生物医学的挑战,至今为止尚未得到满足。

在这里,研究人员报告了一个有机体培养系统,能够从人类多能干细胞产生复杂的皮肤。研究人员使用逐步调节转化生长因子β(TGFβ)和成纤维细胞生长因子(FGF)的信号通路,共同诱导球形细胞集合体内产生颅上皮细胞和神经嵴细胞。

在4-5个月的培育期内,研究人员观察到由分层表皮、富含脂肪的真皮层和带有皮脂腺的色素性毛囊组成的皮肤类器官的出现。

一个由感觉神经元和舒旺细胞组成的网络形成了神经束,这些神经束以类器官毛囊中的默克尔(Merkel)细胞为目标,模仿人类触摸相关的神经回路。

单细胞RNA测序和与胎儿标本的直接比较表明,皮肤类器官毛囊相当于人类胎儿在发育的第二个三个月中的面部皮肤。

此外,研究人员表明,当移植到裸鼠身上时,皮肤器官可以形成平面的毛发皮肤。

因此,这些结果表明,近乎完整的皮肤可以在体外自组装,并可用于在体内重建皮肤。研究人员预计,该皮肤类器官将为未来人类皮肤发育、疾病建模和重建手术的研究提供基础。

 

原始出处:

Jiyoon Lee et al. Hair-bearing human skin generated entirely from pluripotent stem cells, Nature (2020). 

 

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    2021-11-12 湘雅科教

    已拜读,受益匪浅。

    0

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    2021-03-11 liye789132251
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    2020-06-07 lovetcm

    JAK抑制剂靠谱

    0

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    2020-06-07 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

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    2020-06-05 zhishijing

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