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Diabetes：类固醇性激素和性激素结合球蛋白与女性2型糖尿病风险有啥关系？

2017-03-12 xing.T MedSci原创

类固醇性激素性激素结合球蛋白女性2型糖尿病
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由此可见，SHBG和TE是女性2型糖尿病发生的独立危险因素。

目前尚不清楚内源性性激素（ESH）是否与女性2型糖尿病风险存在相关性。近日，糖尿病领域权威杂志Diabetes上发表了一篇研究文章，研究人员通过对参加鹿特丹的研究的3117例绝经后妇女数据进行分析，旨在评估ESH和性激素结合球蛋白（SHBG）与女性2型糖尿病风险之间的相关性。

此外，研究人员还进行了一项系统回顾，并且对评估ESH和SHBG与女性2型糖尿病之间前瞻性相关性研究的荟萃分析。

在平均11.1年的随访中，研究人员在鹿特丹研究中确定了384例2型糖尿病患者。研究人员发现总睾酮水平（TT）或生物活性睾酮（BT）与2型糖尿病之间无相关性。SHBG与2型糖尿病风险呈负相关，而总雌二醇（TE）与2型糖尿病风险增加相关。同样，在13项以人群为基础的前瞻性研究超过1912例2型糖尿病病例的荟萃分析中，低水平的SHBG和高水平的TE与2型糖尿病风险增加相关，而与其他激素没有发现相关性。SHBG与2型糖尿病之间的相关性没有因绝经状态而变化，而ESH与2型糖尿病之间的相关性只有在绝经后妇女的基础上才存在。

由此可见，SHBG和TE是女性2型糖尿病发生的独立危险因素。

原始出处：

Taulant Muka, et al. Associations of Steroid Sex Hormones and Sex Hormone–Binding Globulin With the Risk of Type 2 Diabetes in Women: A Population-Based Cohort Study and Meta-analysis. Diabetes 2017 Mar; 66(3): 577-586. https://doi.org/10.2337/db16-0473

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    2018-01-06 xzw113

    #球蛋白#

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    2017-03-22 海豹

    #性激素结合球蛋白#

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    2017-07-26 木头人513

    #Diabetes#

    0

  4. 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createdName=wangyang7958, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313365, encodeId=414313133658d, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=)]
    2018-01-04 ms9608593228839890

    #DIA#

    0

  5. 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createdName=wangyang7958, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313365, encodeId=414313133658d, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=)]
    2017-04-17 ms5439512287675881

    #BET#

    0

  6. 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createdName=wangyang7958, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313365, encodeId=414313133658d, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=)]
    2017-04-27 方舒

    学习

    0

  7. 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href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Wed Mar 22 19:09:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286364, encodeId=8897128636444, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313365, encodeId=414313133658d, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=)]
    2017-04-26 方舒

    学习

    0

  8. 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createdName=wangyang7958, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313365, encodeId=414313133658d, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=)]
    2017-03-22 ms3994565386320060

    #2型糖尿病风险#

    0

  9. 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createdName=wangyang7958, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313365, encodeId=414313133658d, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=)]
    2017-03-14 wangyang7958

    #性激素#

    0

  10. 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createdName=wangyang7958, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1313365, encodeId=414313133658d, content=<a href='/topic/show?id=d59be61251d' target=_blank style='color:#2F92EE;'>#类固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76125, encryptionId=d59be61251d, topicName=类固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Tue Mar 14 00:09:00 CST 2017, time=2017-03-14, status=1, ipAttribution=)]
    2017-03-14 30397604

    #类固醇#

    0

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