Nature子刊:春节还在喝酒吗?节假日过度饮酒或会导致房颤风险激增!

2022-02-05 MedSci原创 MedSci原创

节假日急性酒精摄入与不连续的房颤发作以及新发房颤的高风险有关。

心房颤动(房颤,AF)是最常见的心律失常,发病率与死亡率均较高。最近,可改变的生活方式因素的重要性已变得很明显,这些因素可能会有意义地影响发生房颤的风险。是世界上最常见的“药物”,已经成为房颤的一个重要危险因素。

越来越多研究显示,长期饮酒是新发房颤的预测因素,戒酒可以降低发生房颤的风险或减少房颤负担。然而,最初的报告表明酒精和房颤之间的关系是指时间上的急性影响。事实上,酒精是任何特定房颤发作的最常见诱因。

这些有限的调查是在阵发性房颤的背景下进行的,目前还没有关于急性饮酒作为首次发病的房颤的先兆的研究。为此,来自美国加州大学旧金山分校的Gregory M. Marcus教授及其团队开展了相关研究,相关结果发表在《自然·心血管研究》杂志上。

研究人员使用商业上可用的、支持蓝牙的呼气式酒精检测设备,从36158人身上共获得了1269054个呼气式酒精测量值。这些人来自美国所有50个州和59个国家。用户每年获得4.06(四分位数范围(IQR),1.25-10.60)次测量的中值。血液酒精浓度或含量(BAC)的中位数是0.04%(IQR,0.0-0.093%)。

经多变量调整后发现,与一年中其他日子相比,在八个主要节假日期间狂饮后,房颤发作风险明显增高(每10万人年719例房颤就诊,P =0.008)。对于从来没发生过房颤的人来说,房颤新发风险更是会大大增加(每10万人年1757例,P < 0.001)。

从36158人身上获得的1269054次呼吸式酒精检测的数据

根据周历日和日历月进行调整,过度饮酒的人群有2640次/10万人年与酒精相关的急诊室就诊事件(95%CI,1903-3376次,P < 0.001)。此外,当血液中BAC在2小时内飙升到0.08%及以上时,就与房颤发作风险增加显著相关。

综上,节假日急性酒精摄入与不连续的房颤发作以及新发房颤的高风险有关。

 

参考文献:

Aung, S., Nah, G., Vittinghoff, E. et al. Population-level analyses of alcohol consumption as a predictor of acute atrial fibrillation episodes. Nat Cardiovasc Res 1, 23–27 (2022). https://doi.org/10.1038/s44161-021-00003-7

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    2022-07-25 liye789132251
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    2022-02-07 guozhenyu
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1885635, encodeId=f0b9188563576, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Jul 25 16:15:13 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764297, encodeId=aa9d1e642974d, content=<a href='/topic/show?id=967b66e9727' target=_blank style='color:#2F92EE;'>#激增#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66797, encryptionId=967b66e9727, topicName=激增)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=faa237702659, createdName=ms1756883563247400, createdTime=Wed Mar 16 08:15:13 CST 2022, time=2022-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385786, encodeId=50da1385e8680, content=<a href='/topic/show?id=526259e00c1' target=_blank style='color:#2F92EE;'>#春节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59700, encryptionId=526259e00c1, topicName=春节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc4b507, createdName=guozhenyu, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507064, encodeId=eb42150e06494, content=<a href='/topic/show?id=dc488685204' target=_blank style='color:#2F92EE;'>#节假日#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86852, encryptionId=dc488685204, topicName=节假日)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79999859496, createdName=hunizi008, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519857, encodeId=2dc0151985e32, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532038, encodeId=d1d615320384c, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1190422, encodeId=856b1190422f7, content=怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=75821577692, createdName=linjianpeng, createdTime=Sun Feb 06 00:16:01 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1190363, encodeId=0be81190363a3, content=学子, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d585243593, createdName=光明骑士, createdTime=Sat Feb 05 19:14:57 CST 2022, time=2022-02-05, status=1, ipAttribution=)]
    2022-02-07 ymljack
  6. [GetPortalCommentsPageByObjectIdResponse(id=1885635, encodeId=f0b9188563576, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Jul 25 16:15:13 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764297, encodeId=aa9d1e642974d, content=<a href='/topic/show?id=967b66e9727' target=_blank style='color:#2F92EE;'>#激增#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66797, encryptionId=967b66e9727, topicName=激增)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=faa237702659, createdName=ms1756883563247400, createdTime=Wed Mar 16 08:15:13 CST 2022, time=2022-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385786, encodeId=50da1385e8680, content=<a href='/topic/show?id=526259e00c1' target=_blank style='color:#2F92EE;'>#春节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59700, encryptionId=526259e00c1, topicName=春节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc4b507, createdName=guozhenyu, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507064, encodeId=eb42150e06494, content=<a href='/topic/show?id=dc488685204' target=_blank style='color:#2F92EE;'>#节假日#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86852, encryptionId=dc488685204, topicName=节假日)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79999859496, createdName=hunizi008, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519857, encodeId=2dc0151985e32, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532038, encodeId=d1d615320384c, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1190422, encodeId=856b1190422f7, content=怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=75821577692, createdName=linjianpeng, createdTime=Sun Feb 06 00:16:01 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1190363, encodeId=0be81190363a3, content=学子, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d585243593, createdName=光明骑士, createdTime=Sat Feb 05 19:14:57 CST 2022, time=2022-02-05, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1885635, encodeId=f0b9188563576, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Jul 25 16:15:13 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764297, encodeId=aa9d1e642974d, content=<a href='/topic/show?id=967b66e9727' target=_blank style='color:#2F92EE;'>#激增#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66797, encryptionId=967b66e9727, topicName=激增)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=faa237702659, createdName=ms1756883563247400, createdTime=Wed Mar 16 08:15:13 CST 2022, time=2022-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385786, encodeId=50da1385e8680, content=<a href='/topic/show?id=526259e00c1' target=_blank style='color:#2F92EE;'>#春节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59700, encryptionId=526259e00c1, topicName=春节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc4b507, createdName=guozhenyu, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507064, encodeId=eb42150e06494, content=<a href='/topic/show?id=dc488685204' target=_blank style='color:#2F92EE;'>#节假日#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86852, encryptionId=dc488685204, topicName=节假日)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79999859496, createdName=hunizi008, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519857, encodeId=2dc0151985e32, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532038, encodeId=d1d615320384c, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1190422, encodeId=856b1190422f7, content=怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=75821577692, createdName=linjianpeng, createdTime=Sun Feb 06 00:16:01 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1190363, encodeId=0be81190363a3, content=学子, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d585243593, createdName=光明骑士, createdTime=Sat Feb 05 19:14:57 CST 2022, time=2022-02-05, status=1, ipAttribution=)]
    2022-02-06 linjianpeng

    怕了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1885635, encodeId=f0b9188563576, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Jul 25 16:15:13 CST 2022, time=2022-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764297, encodeId=aa9d1e642974d, content=<a href='/topic/show?id=967b66e9727' target=_blank style='color:#2F92EE;'>#激增#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66797, encryptionId=967b66e9727, topicName=激增)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=faa237702659, createdName=ms1756883563247400, createdTime=Wed Mar 16 08:15:13 CST 2022, time=2022-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385786, encodeId=50da1385e8680, content=<a href='/topic/show?id=526259e00c1' target=_blank style='color:#2F92EE;'>#春节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59700, encryptionId=526259e00c1, topicName=春节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc4b507, createdName=guozhenyu, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507064, encodeId=eb42150e06494, content=<a href='/topic/show?id=dc488685204' target=_blank style='color:#2F92EE;'>#节假日#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86852, encryptionId=dc488685204, topicName=节假日)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79999859496, createdName=hunizi008, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519857, encodeId=2dc0151985e32, content=<a href='/topic/show?id=506b401e129' target=_blank style='color:#2F92EE;'>#喝酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40171, encryptionId=506b401e129, topicName=喝酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc8811296196, createdName=ymljack, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532038, encodeId=d1d615320384c, content=<a href='/topic/show?id=b0885428229' target=_blank style='color:#2F92EE;'>#房颤风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54282, encryptionId=b0885428229, topicName=房颤风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ea612304943, createdName=whmdzju, createdTime=Mon Feb 07 02:15:13 CST 2022, time=2022-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1190422, encodeId=856b1190422f7, content=怕了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=75821577692, createdName=linjianpeng, createdTime=Sun Feb 06 00:16:01 CST 2022, time=2022-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1190363, encodeId=0be81190363a3, content=学子, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4d585243593, createdName=光明骑士, createdTime=Sat Feb 05 19:14:57 CST 2022, time=2022-02-05, status=1, ipAttribution=)]
    2022-02-05 光明骑士

    学子

    0

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与非糖尿病患者相比,伴有糖尿病的AF患者较少感知到AF症状,但生活质量较差,心脏和神经系统合并症更多。

Clin Res Cardiol:房颤患者发生纤维化性心房心肌病的决定因素

年龄、性别和房颤表型都是纤维性心房肌病发生的主要决定因素

拓展阅读

小酌真怡情!北京协和医学院:适度饮酒,或能保护心血管健康!但别超过这个量......

Frontiers in Cardiovascular Medicine:适度饮酒往往会对肠道微生物组和血清代谢物情况产生积极的影响,或对心血管健康产生益处。

JAMA子刊:超千万人数据,“每日小酌”与“周末豪饮”,究竟哪个更致癌?

胃肠道是最容易受酒精影响的器官之一,流行病学证据显示,饮酒与食道、结直肠和肝脏癌症的风险有关;同时也与胃癌和胰腺癌的高风险有关。

JAMA Network Open:颠覆认知,10年随访研究表明,适量饮酒可以保护大脑功能,提高认知能力

酒精饮料是最重要的饮品之一,在全世界范围内有近20亿名消费者,许多研究已经证实,酗酒会诱发心脑血管疾病、代谢性疾病,甚至于某些癌症的发生也与饮酒密切相关。

J Alzheimers Dis:适量饮酒带来“意想不到”的健康益处

一项新的研究表明,适度饮酒可以降低老年人患老年痴呆症的风险。但该研究的作者强调,这些发现并不意味着可以自由饮酒,这项研究只发现了酒精的摄入和精神的锐度之间的联系,而不是因果联系。

AHA 2016:适度饮酒可能会减缓“好”胆固醇的下降

在一项80000名健康的中国成年人的研究中,适度饮酒与高密度脂蛋白(HDL)的下降有关

乔岩:红酒——法国人的美丽谎言?

法国人喜欢喝红酒,法国人心血管病发病率比其他欧美国家低,这是喝红酒的好处吗?医学证据表明,适量饮酒会升高具有心脏保护作用的好胆固醇,减轻胰岛素抵抗,降低糖尿病和心血管疾病风险,具有一定心脏保护作用。而红葡萄酒除了可以升高好胆固醇,还含有多酚和白藜芦醇等抗氧化剂,改善血管内皮功能,减轻炎症反应,可能有益心脏健康,也会降低肥胖和糖尿病风险。这也是把法国人心血管病死亡率低归结于红酒的主要原因,成为小